奈帕芬胺(英語:Nepafenac,商品名:NevanacIlevro等)是一种含氮有机化合物,分子式C15H14N2O2,属于非甾体抗炎药(NSAID),可作为眼藥水處方藥[3],其在体内的活性代謝產物氨芬酸[4][5]

奈帕芬胺
臨床資料
商品名英语Drug nomenclatureNevanac, Ilevro, Amnac, others
AHFS/Drugs.comMonograph
MedlinePlusa606007
核准狀況
懷孕分級
给药途径Topical eye drops
ATC碼
法律規範狀態
法律規範
识别信息
  • 2-amino-3-benzoylbenzeneacetamide
CAS号78281-72-8  checkY
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.207.414 編輯維基數據鏈接
化学信息
化学式C15H14N2O2
摩尔质量254.29 g·mol−1
3D模型(JSmol英语JSmol
  • O=C(c1cccc(c1N)CC(=O)N)c2ccccc2
  • InChI=1S/C15H14N2O2/c16-13(18)9-11-7-4-8-12(14(11)17)15(19)10-5-2-1-3-6-10/h1-8H,9,17H2,(H2,16,18) checkY
  • Key:QEFAQIPZVLVERP-UHFFFAOYSA-N checkY

参考文献

编辑
  1. ^ Nepafenac ophthalmic Use During Pregnancy. Drugs.com. 6 June 2019 [13 September 2020]. 
  2. ^ Prescription medicines: registration of new chemical entities in Australia, 2015. Therapeutic Goods Administration (TGA). 21 June 2022 [10 April 2023]. 
  3. ^ Nepafenac Monograph
  4. ^ Drugbank: Nepafenac
  5. ^ Zanetti FR, Fulco EA, Chaves FR, da Costa Pinto AP, Arieta CE, Lira RP. Effect of preoperative use of topical prednisolone acetate, ketorolac tromethamine, nepafenac and placebo, on the maintenance of intraoperative mydriasis during cataract surgery: a randomized trial. Indian Journal of Ophthalmology. July 2012, 60 (4): 277–81. PMC 3442462 . PMID 22824596. doi:10.4103/0301-4738.98705 . 

外部链接

编辑
  • Nepafenac. Drug Information Portal. U.S. National Library of Medicine.