托利咪酮

化合物

托利咪酮(英語:Tolimidone,开发代号:CP-26154、MLR-1023)是一种有机化合物,分子式C11H10N2O2,由輝瑞公司的科学家研发,可刺激胃黏膜分泌,輝瑞公司曾计划将其开发为胃及十二指肠潰瘍药物,但因种种原因失败[1][2][3]

托利咪酮
臨床資料
其他名稱CP-26154, MLR-1023
识别信息
  • 5-(3-methylphenoxy)pyrimidin-2(1H)-one
CAS号41964-07-2
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.230.742 編輯維基數據鏈接
化学信息
化学式C11H10N2O2
摩尔质量202.21 g·mol−1
3D模型(JSmol英语JSmol
  • O=C2/N=C\C(\Oc1cc(ccc1)C)=C/N2

参考文献

编辑
  1. ^ Tolimidone. AdisInsight. [26 August 2017]. (原始内容存档于2023-07-27) (英语). 
  2. ^ Lipinski, C. A.; Stam, J. G.; Pereira, J. N.; Ackerman, N. R.; Hess, H. J. Bronchodilator and antiulcer phenoxypyrimidinones. Journal of Medicinal Chemistry. 1980, 23 (9): 1026–31. PMID 7411545. doi:10.1021/jm00183a012. Compound 3 has been assigned the nonproprietary (USAN) name tolimidone 
  3. ^ Lipinski CA, Reaume AG. High throughput in vivo phenotypic screening for drug repurposing: Discovery of MLR-1023 a novel insulin sensitizer and novel Lyn kinase activator with clinical proof of concept. Bioorg Med Chem. May 2020, 28 (8): 115425. PMID 32201192. doi:10.1016/j.bmc.2020.115425 . 

外部链接

编辑