丙帕他莫

化合物

丙帕他莫扑热息痛前药,由扑热息痛和羧酸二乙基甘氨酸酯化形成。这具有使其更易溶于水的优点。它用于术后透过静脉注射护理无法以口服或直肠给药扑热息痛,并且禁用非甾体抗炎药(NSAID)的患者。丙帕他莫起效比口服扑热息痛快。 [3] 2克丙帕他莫相当于1 克扑热息痛的药效。 [4]

丙帕他莫
临床资料
AHFS/Drugs.com国际药品名称
给药途径IV[1][2]
ATC码
药物动力学数据
生物半衰期2.4小时 [1]
排泄途径经由肾脏
识别信息
  • 4-(acetamido)phenyl N,N-diethylglycinate
CAS号66532-85-2
PubChem CID
ChemSpider
UNII
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.060.336 编辑维基数据链接
化学信息
化学式C14H20N2O3
摩尔质量264.33 g·mol−1
3D模型(JSmol英语JSmol
  • CCN(CC)CC(=O)OC1=CC=C(C=C1)NC(=O)C
  • InChI=1S/C14H20N2O3/c1-4-16(5-2)10-14(18)19-13-8-6-12(7-9-13)15-11(3)17/h6-9H,4-5,10H2,1-3H3,(H,15,17)
  • Key:QTGAJCQTLIRCFL-UHFFFAOYSA-N

相关条目

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参考资料

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  1. ^ 1.0 1.1 Bannwarth B, Netter P, Lapicque F, Gillet P, Péré P, Boccard E, Royer RJ, Gaucher A. Plasma and cerebrospinal fluid concentrations of paracetamol after a single intravenous dose of propacetamol. British Journal of Clinical Pharmacology. 1992, 34 (1): 79–81. PMC 1381380 . PMID 1633071. doi:10.1111/j.1365-2125.1992.tb04112.x. 
  2. ^ Binhas M, Decailliot F, Rezaiguia-Delclaux S, Suen P, Dumerat M, François V, Combes X, Duvaldestin P. Comparative effect of intraoperative propacetamol versus placebo on morphine consumption after elective reduction mammoplasty under remifentanil-based anesthesia: a randomized control trial [ISRCTN71723173]. BMC Anesthesiology. 2004, 4 (1): 6. PMC 520811 . PMID 15367329. doi:10.1186/1471-2253-4-6. 
  3. ^ Onset of acetaminophen analgesia: comparison of oral and intravenous routes after third molar surgery. British Journal of Anaesthesiology. 2005, 94 (5): 642–648. PMID 15790675. doi:10.1093/bja/aei109. 
  4. ^ Bioequivalence study comparing a new paracetamol solution for injection and propacetamol after single intravenous infusion in healthy subjects. International Journal of Clinical Pharmacology and Therapeutics. 2004, 42 (1): 50–57. PMID 14756388. doi:10.5414/cpp42050.