丙帕他莫

丙帕他莫
臨床資料
AHFS/Drugs.com	国际药品名称
给药途径	IV
ATC碼	N02BE05 (WHO) ;
藥物動力學數據
生物半衰期	2.4小時
排泄途徑	經由腎臟
识别信息
	IUPAC命名法 4-(acetamido)phenyl N,N-diethylglycinate; ;
CAS号	66532-85-2
PubChem CID	68865;
ChemSpider	62097;
UNII	5CHW4JMR82;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID3057800 ;
ECHA InfoCard	100.060.336
化学信息
化学式	C14H20N2O3
摩尔质量	264.33 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES CCN(CC)CC(=O)OC1=CC=C(C=C1)NC(=O)C;
	InChI InChI=1S/C14H20N2O3/c1-4-16(5-2)10-14(18)19-13-8-6-12(7-9-13)15-11(3)17/h6-9H,4-5,10H2,1-3H3,(H,15,17); Key:QTGAJCQTLIRCFL-UHFFFAOYSA-N;

丙帕他莫是扑热息痛的前药，由扑热息痛和羧酸二乙基甘氨酸酯化形成。这具有使其更易溶于水的优点。它用于术后透过静脈注射护理无法以口服或直肠给药扑热息痛，并且禁用非甾体抗炎药(NSAID)的患者。丙帕他莫起效比口服扑热息痛快。 ^[3] 2克丙帕他莫相当于1 克扑热息痛的藥效。 ^[4]

参考資料

^ ^1.0 ^1.1 Bannwarth B, Netter P, Lapicque F, Gillet P, Péré P, Boccard E, Royer RJ, Gaucher A. Plasma and cerebrospinal fluid concentrations of paracetamol after a single intravenous dose of propacetamol. British Journal of Clinical Pharmacology. 1992, 34 (1): 79–81. PMC 1381380  . PMID 1633071. doi:10.1111/j.1365-2125.1992.tb04112.x.
^ Binhas M, Decailliot F, Rezaiguia-Delclaux S, Suen P, Dumerat M, François V, Combes X, Duvaldestin P. Comparative effect of intraoperative propacetamol versus placebo on morphine consumption after elective reduction mammoplasty under remifentanil-based anesthesia: a randomized control trial [ISRCTN71723173]. BMC Anesthesiology. 2004, 4 (1): 6. PMC 520811  . PMID 15367329. doi:10.1186/1471-2253-4-6.
^ Onset of acetaminophen analgesia: comparison of oral and intravenous routes after third molar surgery. British Journal of Anaesthesiology. 2005, 94 (5): 642–648. PMID 15790675. doi:10.1093/bja/aei109.
^ Bioequivalence study comparing a new paracetamol solution for injection and propacetamol after single intravenous infusion in healthy subjects. International Journal of Clinical Pharmacology and Therapeutics. 2004, 42 (1): 50–57. PMID 14756388. doi:10.5414/cpp42050.