去甲替林

化合物

去甲替林(英语:Nortriptyline,商品名Pamelor)是一种有机化合物,分子式C19H21N,为阿米替林代谢产物,是一种三环类抗抑郁药(TCA)。[3][4]

去甲替林
Skeletal formula of nortriptyline
Ball-and-stick model of the nortriptyline molecule
临床资料
商品名英语Drug nomenclaturePamelor, Noritren, Nortrilen, others
其他名称Desitriptyline; ELF-101; E.L.F. 101; N-7048
AHFS/Drugs.comMonograph
MedlinePlusa682620
核准状况
怀孕分级
给药途径口服
药物类别英语Drug class三环类抗抑郁药(TCA)
ATC码
法律规范状态
法律规范
药物动力学数据
生物利用度32–79[2]
血浆蛋白结合率92%[2]
药物代谢Liver
代谢产物10-E-Hydroxynortriptyline
生物半衰期18–44 hours (mean 30 hours)[2]
排泄途径Urine: 40%[2]
Feces: minor[2]
识别信息
  • 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
CAS号72-69-5  checkY
894-71-3盐酸盐
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.000.717 编辑维基数据链接
化学信息
化学式C19H21N
摩尔质量263.38 g·mol−1
3D模型(JSmol英语JSmol
  • c3cc2c(/C(c1c(cccc1)CC2)=C/CCNC)cc3
  • InChI=1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-11,20H,6,12-14H2,1H3 checkY
  • Key:PHVGLTMQBUFIQQ-UHFFFAOYSA-N checkY

参考资料

编辑
  1. ^ Nortriptyline Use During Pregnancy. Drugs.com. 22 June 2020 [10 October 2020]. (原始内容存档于2023-08-06). 
  2. ^ 2.0 2.1 2.2 2.3 2.4 Lemke TL, Williams DA. Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. 24 January 2012: 588–. ISBN 978-1-60913-345-0. 
  3. ^ British national formulary : BNF 76 76. Pharmaceutical Press. 2018: 374. ISBN 9780857113382. 
  4. ^ Nortriptyline Hydrochloride Monograph for Professionals. Drugs.com. American Society of Health-System Pharmacists. [22 March 2019]. (原始内容存档于2019-03-28) (英语). 

外部链接

编辑
  • Nortriptyline. Drug Information Portal. U.S. National Library of Medicine. [2023-08-06]. (原始内容存档于2022-11-27).