美雌醇

化合物

美雌醇(英语:Mestranol,或称为炔雌醇甲醚,商品名有Enovid、Norinyl、Ortho-Novum等),分子式C21H26O2,是一种雌激素药物,代谢产物炔雌醇[4],作为复合口服避孕药[5]月经失调激素替代疗法药物[6]

美雌醇
临床资料
商品名英语Drug nomenclatureEnovid, Norinyl, Ortho-Novum, others
其他名称Ethinylestradiol 3-methyl ether; EEME; EE3ME; CB-8027; L-33355; RS-1044; 17α-Ethynylestradiol 3-methyl ether; 17α-Ethynyl-3-methoxyestra-1,3,5(10)-trien-17β-ol; 3-Methoxy-19-norpregna-1,3,5(10)-trien-20-yn-17β-ol
AHFS/Drugs.com国际药品名称
MedlinePlusa601050
给药途径口服给药[1]
药物类别英语Drug class雌激素; Estrogen ether
ATC码
  • 未分配
法律规范状态
法律规范
  • 处方药(-only)
药物动力学数据
代谢产物炔雌醇
生物半衰期Mestranol: 50 分钟[2]
EE: 7–36 小时[3][4][5][6]
识别信息
  • (8R,9S,13S,14S,17R)-17-ethynyl-3-methoxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-ol
CAS号72-33-3  checkY
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.000.707 编辑维基数据链接
化学信息
化学式C21H26O2
摩尔质量310.44 g·mol−1
3D模型(JSmol英语JSmol
  • O(c1cc4c(cc1)[C@H]3CC[C@]2([C@@H](CC[C@]2(C#C)O)[C@@H]3CC4)C)C
  • InChI=1S/C21H26O2/c1-4-21(22)12-10-19-18-7-5-14-13-15(23-3)6-8-16(14)17(18)9-11-20(19,21)2/h1,6,8,13,17-19,22H,5,7,9-12H2,2-3H3/t17-,18-,19+,20+,21+/m1/s1 checkY
  • Key:IMSSROKUHAOUJS-MJCUULBUSA-N checkY

参考文献

编辑
  1. ^ I.K. Morton; Judith M. Hall. Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. 6 December 2012: 177–. ISBN 978-94-011-4439-1. 
  2. ^ Benno Runnebaum; Thomas Rabe. Gynäkologische Endokrinologie und Fortpflanzungsmedizin: Band 1: Gynäkologische Endokrinologie. Springer-Verlag. 17 April 2013: 88– [2022-11-27]. ISBN 978-3-662-07635-4. (原始内容存档于2022-10-14). 
  3. ^ Claude L Hughes; Michael D. Waters. Translational Toxicology: Defining a New Therapeutic Discipline. Humana Press. 23 March 2016: 73–. ISBN 978-3-319-27449-2. 
  4. ^ 4.0 4.1 Goldzieher JW, Brody SA. Pharmacokinetics of ethinyl estradiol and mestranol. American Journal of Obstetrics and Gynecology. 1990, 163 (6 Pt 2): 2114–9. PMID 2256522. doi:10.1016/0002-9378(90)90550-Q. 
  5. ^ 5.0 5.1 Stanczyk FZ, Archer DF, Bhavnani BR. Ethinyl estradiol and 17β-estradiol in combined oral contraceptives: pharmacokinetics, pharmacodynamics and risk assessment. Contraception. 2013, 87 (6): 706–27. PMID 23375353. doi:10.1016/j.contraception.2012.12.011. 
  6. ^ 6.0 6.1 Shellenberger, T. E. Pharmacology of estrogens. 1986: 393–410. ISBN 978-94-010-8339-3. doi:10.1007/978-94-009-4145-8_36.  |journal=被忽略 (帮助); 缺少或|title=为空 (帮助)

外部链接

编辑