双环铂是一种化疗药物,用于治疗包括非小细胞肺癌前列腺癌在内的多种癌症。[1]

双环铂
双环铂的化学结构
临床资料
商品名英语Drug nomenclatureDicycloplatin
其他名称Platinum(2+) 1-carboxycyclobutanecarboxylate ammoniate (1:2:2), 1,1-Cyclobutanedicarboxylic acid, compd. with (sp-4-2)-diammine(1,1-cyclobutanedi(carboxylato-kappaO)(2-))platinum (1:1)
给药途径Intravenous
药物动力学数据
生物利用度100% (IV)
血浆蛋白结合率< 88.7%
生物半衰期24.49 - 108.93 hours
排泄途径Renal
识别信息
  • azane;cyclobutane-1,1-dicarboxylate;cyclobutane-1,1-dicarboxylic acid;platinum(2+)
CAS号287402-09-9  checkY
ChemSpider
UNII
化学信息
化学式C12H20N2O8Pt
摩尔质量515.382 g/mol
3D模型(JSmol英语JSmol
  • C1CC(C1)(C(=O)O)C(=O)O.C1CC(C1)(C(=O)[O-])C(=O)[O-].N.N.[Pt+2]
  • InChI=InChI=1S/2C6H8O4.2H3N.Pt/c2*7-4(8)6(5(9)10)2-1-3-6;;;/h2*1-3H2,(H,7,8)(H,9,10);2*1H3;/q;;;;+2/p-2 checkY
  • Key:IIJQICKYWPGJDT-UHFFFAOYSA-L checkY

双环铂治疗过程中观察到的副作用包括恶心呕吐血小板减少嗜中性白血球低下贫血疲劳厌食肝酶升高和脱发等。这些药物是铂基抗肿瘤药物的一种,它的作用方式是使线粒体功能障碍,导致细胞死亡。[2].

参考文献

编辑
  1. ^ D., Zhao; Y., Zhang; C., Xu; C., Dong; H., Lin; L., Zhang; C., Li; S., Ren; X., Wang; S., Yang; D., Han; X., Chen. Pharmacokinetics, Tissue Distribution, and Plasma Protein Binding Study of Platinum Originating from Dicycloplatin, a Novel Antitumor Supramolecule, in Rats and Dogs by ICP-MS. Biological Trace Element Research. February 2012, 148: 203–208. doi:10.1007/s12011-012-9364-2. 
  2. ^ G.Q., Li; X.G., Chen; X.P., Wu; J.D., Xie; Y.J., Liang; X.Q., Zhao; W.Q, Chen; L.W., Fu. Effect of Dicycloplatin, a Novel Platinum Chemotherapeutical Drug, on Inhibiting Cell Growth and Inducing Cell Apoptosis. PLOS ONE. November 2012, 7 (11). doi:10.1371/journal.pone.0048994.