雙環鉑是一種化療藥物,用於治療包括非小細胞肺癌前列腺癌在內的多種癌症。[1]

雙環鉑
雙環鉑的化學結構
臨床資料
商品名英語Drug nomenclatureDicycloplatin
其他名稱Platinum(2+) 1-carboxycyclobutanecarboxylate ammoniate (1:2:2), 1,1-Cyclobutanedicarboxylic acid, compd. with (sp-4-2)-diammine(1,1-cyclobutanedi(carboxylato-kappaO)(2-))platinum (1:1)
給藥途徑Intravenous
藥物動力學數據
生物利用度100% (IV)
血漿蛋白結合率< 88.7%
生物半衰期24.49 - 108.93 hours
排泄途徑Renal
識別資訊
  • azane;cyclobutane-1,1-dicarboxylate;cyclobutane-1,1-dicarboxylic acid;platinum(2+)
CAS號287402-09-9  checkY
ChemSpider
UNII
化學資訊
化學式C12H20N2O8Pt
摩爾質量515.382 g/mol
3D模型(JSmol英語JSmol
  • C1CC(C1)(C(=O)O)C(=O)O.C1CC(C1)(C(=O)[O-])C(=O)[O-].N.N.[Pt+2]
  • InChI=InChI=1S/2C6H8O4.2H3N.Pt/c2*7-4(8)6(5(9)10)2-1-3-6;;;/h2*1-3H2,(H,7,8)(H,9,10);2*1H3;/q;;;;+2/p-2 checkY
  • Key:IIJQICKYWPGJDT-UHFFFAOYSA-L checkY

雙環鉑治療過程中觀察到的副作用包括噁心嘔吐血小板減少嗜中性白血球低下貧血疲勞厭食肝酶升高和脫髮等。這些藥物是鉑基抗腫瘤藥物的一種,它的作用方式是使線粒體功能障礙,導致細胞死亡。[2].

參考文獻

編輯
  1. ^ D., Zhao; Y., Zhang; C., Xu; C., Dong; H., Lin; L., Zhang; C., Li; S., Ren; X., Wang; S., Yang; D., Han; X., Chen. Pharmacokinetics, Tissue Distribution, and Plasma Protein Binding Study of Platinum Originating from Dicycloplatin, a Novel Antitumor Supramolecule, in Rats and Dogs by ICP-MS. Biological Trace Element Research. February 2012, 148: 203–208. doi:10.1007/s12011-012-9364-2. 
  2. ^ G.Q., Li; X.G., Chen; X.P., Wu; J.D., Xie; Y.J., Liang; X.Q., Zhao; W.Q, Chen; L.W., Fu. Effect of Dicycloplatin, a Novel Platinum Chemotherapeutical Drug, on Inhibiting Cell Growth and Inducing Cell Apoptosis. PLOS ONE. November 2012, 7 (11). doi:10.1371/journal.pone.0048994.