穀氨酰氨基肽酶
穀氨酰氨基肽酶，又稱氨基肽酶A，舊稱血管緊張素酶A[1]。它由ENPEP基因編碼，且高度保守[2]。穀氨酰氨基肽酶是一種膜結合鋅蛋白，能催化穀氨酸和天冬氨酸從肽鏈的N末端水解。例如，把血管緊張素IIN末端天冬氨酸水解而轉化血管緊張素III。這個降解過程是哺乳動物調節局部血壓的一個重要步驟[1][3]。穀氨酰氨基肽酶被指定為CD249。
| 穀氨酰氨基肽酶 (氨基肽酶A) | |
|---|---|
| 識別 | |
| 符號 | ENPEP |
| 替換符號 | gp160, CD249 |
| Entrez | 2028 |
| HUGO | 3355 |
| OMIM | 138297 |
| RefSeq | NM_001977 |
| UniProt | Q07075 |
| 其他資料 | |
| EC編號 | 3.4.11.7 |
| 基因座 | 4 q25 |
參考文獻
編輯- ^ 1.0 1.1 Kugler P. Aminopeptidase A is angiotensinase A. II. Biochemical studies on aminopeptidase A and M in rat kidney homogenate.. Histochemistry. 1982, 74 (2): 247–61. PMID 6129208.
- ^ Li L, Wu Q, Wang J, Bucy RP, Cooper MD. Widespread tissue distribution of aminopeptidase A, an evolutionarily conserved ectoenzyme recognized by the BP-1 antibody.. Tissue Antigens. 1993, 42 (5): 488 – 96. PMID 8146860.
- ^ Reaux A, Iturrioz X, Vazeux G, Fournie-Zaluski MC, David C, Roques BP, Corvol P, Llorens-Cortes C. Aminopeptidase A, which generates one of the main effector peptides of the brain renin-angiotensin system, angiotensin III, has a key role in central control of arterial blood pressure. Biochem. Soc. Trans. 2000, 28 (4): 435–40. PMID 10961935.