絨毛羊膜炎,又名為內羊膜炎(intra-amniotic inflammationIAI),是胎膜羊水胎盤炎症,常由感染引起[2] [3]。症狀通常包括發燒、腹痛、母親或胎兒心率過快、或異常的陰道分泌物[4]。新生兒併發症可能包括肺炎腦膜炎敗血症早產腦性麻痺[3] [5]。母親的併發症可能包括產後出血子宮內膜炎敗血症急性呼吸窘迫症候群[3]

絨毛羊膜炎
顯微圖顯示急性絨毛膜羊膜炎,絨毛膜中有中性粒細胞。還有纖維蛋白血栓,代表嚴重的胎兒發炎反應。[1]蘇木精-伊紅染色.
分類和外部資源
醫學專科婦產科學
ICD-10O41.1、​P02.7
DiseasesDB31882
eMedicine973237
[編輯此條目的維基數據]

危險因子包括分娩時間較長胎膜早破、既往妊娠次數少、產道內有B 組鏈球菌移生和胎膜破裂後頻繁地進行陰道檢查[3] [6]。可能的機轉通常是細菌陰道進入子宮[4] [7]。引起發炎,並造成子宮收縮,並可能早產[7]。若出現單次體溫超過39.0 °C(102.2 °F)或持續在38.0 °C(100.4 °F)和39.0 °C(102.2 °F)間,就需高度懷疑患者是否有這個診斷 [3]

使用抗生素治療,常用氨苄西林慶大黴素[3] [6]。可用乙酰氨基酚(對乙酰氨基酚)降低體溫[6]。有早產風險的患者,也可能使用皮質類固醇[5]。雖然通常應該及時進行生產,但通常不需剖腹產[3] [6]。羊膜囊早期破裂的患者,通常會預防性使用抗生素[5]

絨毛膜羊膜炎的發生率,在足月產約為 4%,在早產則約在 40% 至 70%,而懷孕不足 24 周的生產中則約為 94%[2] [8]。分娩時的發燒,有 10% 至 40% 是由此引起[9]


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參考文獻

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  1. ^ Kim CJ, Romero R, Chaemsaithong P, Chaiyasit N, Yoon BH, Kim YM. Acute chorioamnionitis and funisitis: definition, pathologic features, and clinical significance. American Journal of Obstetrics and Gynecology. October 2015, 213 (4 Suppl): S29–S52. PMC 4774647 . PMID 26428501. doi:10.1016/j.ajog.2015.08.040. 
  2. ^ 2.0 2.1 Kim, Chong Jai; Romero, Roberto; Chaemsaithong, Piya; Chaiyasit, Noppadol; Yoon, Bo Hyun; Kim, Yeon Mee. Acute chorioamnionitis and funisitis: definition, pathologic features, and clinical significance. American Journal of Obstetrics and Gynecology. 2015, 213 (4): S29–S52. ISSN 0002-9378. PMC 4774647 . PMID 26428501. doi:10.1016/j.ajog.2015.08.040. 
  3. ^ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Committee Opinion No. 712: Intrapartum Management of Intraamniotic Infection.. Obstetrics and gynecology. August 2017, 130 (2): e95-e101 [17 January 2024]. PMID 28742677. doi:10.1097/AOG.0000000000002236. (原始內容存檔於26 September 2023). 
  4. ^ 4.0 4.1 Fowler, JR; Simon, LV. Chorioamnionitis.. StatPearls. January 2023 [17 January 2024]. PMID 30335284. (原始內容存檔於31 January 2021). 
  5. ^ 5.0 5.1 5.2 Ericson JE, Laughon MM. Chorioamnionitis: implications for the neonate. Clinics in Perinatology. March 2015, 42 (1): 155–65, ix. PMC 4331454 . PMID 25678002. doi:10.1016/j.clp.2014.10.011. 
  6. ^ 6.0 6.1 6.2 6.3 Intraamniotic Infection - Gynecology and Obstetrics. Merck Manuals Professional Edition. [17 January 2024]. (原始內容存檔於2 October 2023) (加拿大英語). 
  7. ^ 7.0 7.1 Galinsky R, Polglase GR, Hooper SB, Black MJ, Moss TJ. The consequences of chorioamnionitis: preterm birth and effects on development. Journal of Pregnancy. 2013, 2013: 412831. PMC 3606792 . PMID 23533760. doi:10.1155/2013/412831 . 
  8. ^ Radswiki, The. Chorioamnionitis | Radiology Reference Article | Radiopaedia.org. Radiopaedia. [18 January 2024]. (原始內容存檔於16 December 2023). 
  9. ^ Gravett, Michael G. Intra-amniotic and Postpartum Infections. The Global Library of Women's Medicine. 2009 [18 January 2024]. doi:10.3843/GLOWM.10176. (原始內容存檔於24 September 2023). 
  • Verani JR, McGee L, Schrag SJ. Prevention of perinatal group B streptococcal disease--revised guidelines from CDC, 2010. MMWR. Recommendations and Reports. November 2010, 59 (RR-10): 1–36. PMID 21088663. 

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