胞移作用

胞移作用（英語：Transcytosis）是指大分子通過細胞的內部，大分子是在細胞的某一側以囊泡進入細胞，穿越整個細胞，再從另一側出去。這些大分子包含抗體中的IgA^[1]、運鐵蛋白^[2]以及胰島素^[3]。最常發生胞移作用的細胞是上皮細胞，但其他組織的細胞諸如血管中的微血管^[4]就經常被提及；其他可以看到此一現象的組織有神經細胞^[5]、蝕骨細胞^[6]、小腸中的微皺細胞^[7]

調控

胞移作用在不同的組織中變化甚大，許多組織的胞移作用的特殊點被標示出來。布雷非德菌素A通常被用來當作內質網到高爾基體之囊狀小泡的阻斷劑，最先在狗的腎臟細胞中在發現自然界中的胞移作用^[8]。另外在表層細胞膜上可以發現RAB17^[9]、RAB11A'^[10]

參考文獻

^ J. H. Perez, W. J. Branch, L. Smith, B. M. Mullock, J. P. Luzio. Investigation of endosomal compartments involved in endocytosis and transcytosis of polymeric immunoglobulin A by subcellular fractionation of perfused isolated rat liver. The Biochemical Journal. 1988-05-01, 251 (3): 763–770 [2019-07-11]. ISSN 0264-6021. PMC 1149069  . PMID 3415644. doi:10.1042/bj2510763. （原始內容存檔於2016-10-01）.
^ J. B. Fishman, J. B. Rubin, J. V. Handrahan, J. R. Connor, R. E. Fine. Receptor-mediated transcytosis of transferrin across the blood-brain barrier. Journal of Neuroscience Research. 1987, 18 (2): 299–304 [2019-07-11]. ISSN 0360-4012. PMID 3694713. doi:10.1002/jnr.490180206. （原始內容存檔於2016-03-24）.
^ K. R. Duffy, W. M. Pardridge. Blood-brain barrier transcytosis of insulin in developing rabbits. Brain Research. 1987-09-08, 420 (1): 32–38 [2019-07-11]. ISSN 0006-8993. PMID 3315116. doi:10.1016/0006-8993(87)90236-8. （原始內容存檔於2015-04-09）.
^ S. K. Williams, D. A. Greener, N. J. Solenski. Endocytosis and exocytosis of protein in capillary endothelium. Journal of Cellular Physiology. 1984-08, 120 (2): 157–162 [2019-07-11]. ISSN 0021-9541. PMID 6430919. doi:10.1002/jcp.1041200208. （原始內容存檔於2019-08-19）.
^ R. H. Fabian. Retrograde axonal transport and transcytosis of immunoglobulins: implications for the pathogenesis of autoimmune motor neuron disease. Advances in Neurology. 1991, 56: 433–444 [2019-07-11]. ISSN 0091-3952. PMID 1853776. （原始內容存檔於2019-08-24）.
^ J. Salo, P. Lehenkari, M. Mulari, K. Metsikkö, H. K. Väänänen. Removal of osteoclast bone resorption products by transcytosis. Science (New York, N.Y.). 1997-04-11, 276 (5310): 270–273 [2019-07-11]. ISSN 0036-8075. PMID 9092479. doi:10.1126/science.276.5310.270. （原始內容存檔於2019-08-20）.
^ T. Landsverk. The follicle-associated epithelium of the ileal Peyer's patch in ruminants is distinguished by its shedding of 50 nm particles. Immunology and Cell Biology. 1987-06,. 65 ( Pt 3): 251–261 [2019-07-11]. ISSN 0818-9641. PMID 3623609. doi:10.1038/icb.1987.28. （原始內容存檔於2019-08-14）.
^ M. E. Taub, W. C. Shen. Regulation of pathways within cultured epithelial cells for the transcytosis of a basal membrane-bound peroxidase-polylysine conjugate. Journal of Cell Science. 1993-12,. 106 ( Pt 4): 1313–1321 [2019-07-11]. ISSN 0021-9533. PMID 8126110. （原始內容存檔於2019-08-24）.
^ W. Hunziker, P. J. Peters. Rab17 localizes to recycling endosomes and regulates receptor-mediated transcytosis in epithelial cells. The Journal of Biological Chemistry. 1998-06-19, 273 (25): 15734–15741 [2019-07-11]. ISSN 0021-9258. PMID 9624171. doi:10.1074/jbc.273.25.15734. （原始內容存檔於2019-08-19）.
^ J. E. Casanova, X. Wang, R. Kumar, S. G. Bhartur, J. Navarre, J. E. Woodrum, Y. Altschuler, G. S. Ray, J. R. Goldenring. Association of Rab25 and Rab11a with the apical recycling system of polarized Madin-Darby canine kidney cells. Molecular Biology of the Cell. 1999-01, 10 (1): 47–61 [2019-07-11]. ISSN 1059-1524. PMC 25153  . PMID 9880326. doi:10.1091/mbc.10.1.47. （原始內容存檔於2019-08-27）.

外部連結

Macromolecules Can Be Transferred Across Epithelial Cell Sheets by Transcytosis （頁面存檔備份，存於互聯網檔案館）
Transcytosis of IgA （頁面存檔備份，存於互聯網檔案館）
Transcytosis of bacteria

[1] J. H. Perez, W. J. Branch, L. Smith, B. M. Mullock, J. P. Luzio. Investigation of endosomal compartments involved in endocytosis and transcytosis of polymeric immunoglobulin A by subcellular fractionation of perfused isolated rat liver. The Biochemical Journal. 1988-05-01, 251 (3): 763–770 [2019-07-11]. ISSN 0264-6021. PMC 1149069  . PMID 3415644. doi:10.1042/bj2510763. （原始內容存檔於2016-10-01）.

[2] J. B. Fishman, J. B. Rubin, J. V. Handrahan, J. R. Connor, R. E. Fine. Receptor-mediated transcytosis of transferrin across the blood-brain barrier. Journal of Neuroscience Research. 1987, 18 (2): 299–304 [2019-07-11]. ISSN 0360-4012. PMID 3694713. doi:10.1002/jnr.490180206. （原始內容存檔於2016-03-24）.

[3] K. R. Duffy, W. M. Pardridge. Blood-brain barrier transcytosis of insulin in developing rabbits. Brain Research. 1987-09-08, 420 (1): 32–38 [2019-07-11]. ISSN 0006-8993. PMID 3315116. doi:10.1016/0006-8993(87)90236-8. （原始內容存檔於2015-04-09）.

[4] S. K. Williams, D. A. Greener, N. J. Solenski. Endocytosis and exocytosis of protein in capillary endothelium. Journal of Cellular Physiology. 1984-08, 120 (2): 157–162 [2019-07-11]. ISSN 0021-9541. PMID 6430919. doi:10.1002/jcp.1041200208. （原始內容存檔於2019-08-19）.

[5] R. H. Fabian. Retrograde axonal transport and transcytosis of immunoglobulins: implications for the pathogenesis of autoimmune motor neuron disease. Advances in Neurology. 1991, 56: 433–444 [2019-07-11]. ISSN 0091-3952. PMID 1853776. （原始內容存檔於2019-08-24）.

[6] J. Salo, P. Lehenkari, M. Mulari, K. Metsikkö, H. K. Väänänen. Removal of osteoclast bone resorption products by transcytosis. Science (New York, N.Y.). 1997-04-11, 276 (5310): 270–273 [2019-07-11]. ISSN 0036-8075. PMID 9092479. doi:10.1126/science.276.5310.270. （原始內容存檔於2019-08-20）.

[7] T. Landsverk. The follicle-associated epithelium of the ileal Peyer's patch in ruminants is distinguished by its shedding of 50 nm particles. Immunology and Cell Biology. 1987-06,. 65 ( Pt 3): 251–261 [2019-07-11]. ISSN 0818-9641. PMID 3623609. doi:10.1038/icb.1987.28. （原始內容存檔於2019-08-14）.

[8] M. E. Taub, W. C. Shen. Regulation of pathways within cultured epithelial cells for the transcytosis of a basal membrane-bound peroxidase-polylysine conjugate. Journal of Cell Science. 1993-12,. 106 ( Pt 4): 1313–1321 [2019-07-11]. ISSN 0021-9533. PMID 8126110. （原始內容存檔於2019-08-24）.

[9] W. Hunziker, P. J. Peters. Rab17 localizes to recycling endosomes and regulates receptor-mediated transcytosis in epithelial cells. The Journal of Biological Chemistry. 1998-06-19, 273 (25): 15734–15741 [2019-07-11]. ISSN 0021-9258. PMID 9624171. doi:10.1074/jbc.273.25.15734. （原始內容存檔於2019-08-19）.

[10] J. E. Casanova, X. Wang, R. Kumar, S. G. Bhartur, J. Navarre, J. E. Woodrum, Y. Altschuler, G. S. Ray, J. R. Goldenring. Association of Rab25 and Rab11a with the apical recycling system of polarized Madin-Darby canine kidney cells. Molecular Biology of the Cell. 1999-01, 10 (1): 47–61 [2019-07-11]. ISSN 1059-1524. PMC 25153  . PMID 9880326. doi:10.1091/mbc.10.1.47. （原始內容存檔於2019-08-27）.

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