CXCL9(英語:Chemokine (C-X-C motif) ligand 9)是一小分子的細胞因子屬於CXC趨化因子家族,又被稱作「干擾素伽瑪誘導的單核白血球因子」(Monokine induced by gamma interferon, MIG)[5] 。CXCL9是T細胞趨化因子[5]干擾素伽瑪誘導CXCL9的表達。人類的CXCL9與CXCL10CXCL11的基因相鄰聚集在第四染色體上[6] 。CXCL9,CXCL10, CXCL11結合趨化因子受體CXCR3而起其細胞趨化作用[7][8]

CXCL9
識別號
別名CXCL9;, CMK, Humig, MIG, SCYB9, crg-10, C-X-C motif chemokine ligand 9
外部IDOMIM601704 MGI1352449 HomoloGene1813 GeneCardsCXCL9
基因位置(人類
4號染色體
染色體4號染色體[1]
4號染色體
CXCL9的基因位置
CXCL9的基因位置
基因座4q21.1起始76,001,275 bp[1]
終止76,007,509 bp[1]
RNA表達模式
查閱更多表達數據
直系同源
物種人類小鼠
Entrez
Ensembl
UniProt
mRNA​序列

NM_002416

NM_008599

蛋白序列

NP_002407

NP_032625

基因位置​(UCSC)Chr 4: 76 – 76.01 MbChr 5: 92.47 – 92.48 Mb
PubMed​查找[3][4]
維基數據
檢視/編輯人類檢視/編輯小鼠

參見

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參考文獻

編輯
  1. ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000138755 - Ensembl, May 2017
  2. ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000029417 - Ensembl, May 2017
  3. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  4. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ 5.0 5.1 Liao F, Rabin RL, Yannelli JR, Koniaris LG, Vanguri P, Farber JM. Human Mig chemokine: biochemical and functional characterization. J Exp Med. 1995 Nov 1;182(5):1301-14.
  6. ^ Lee HH, Farber JM. Localization of the gene for the human MIG cytokine on chromosome 4q21 adjacent to INP10 reveals a chemokine "mini-cluster". Cytogenet Cell Genet. 1996;74(4):255-8.
  7. ^ Loetscher M, Gerber B, Loetscher P, Jones SA, Piali L, Clark-Lewis I, Baggiolini M, Moser B. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. J Exp Med. 1996 Sep 1;184(3):963-9.
  8. ^ Weng Y, Siciliano SJ, Waldburger KE, Sirotina-Meisher A, Staruch MJ, Daugherty BL, Gould SL, Springer MS, DeMartino JA. Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors. J Biol Chem. 1998 Jul 17;273(29):18288-91.

外部連結

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