別孕烷醇酮
化合物
別孕烷醇酮(英語:allopregnanolone,ALLO,也名為3α,5α-孕烷醇酮)是一種作用於大腦的神經甾體[2][3],可用於治療產後抑鬱症[3][4][5]。
臨床資料 | |
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商品名 | Zulresso |
其他名稱 | ALLO; Allo; ALLOP; AlloP; Brexanolone; SAGE-547; SGE-102; 5α-Pregnan-3α-ol-20-one; 3α-Hydroxy-5α-pregnan-20-one; 3α,5α-Tetrahydroprogesterone; 3α,5α-THP |
給藥途徑 | Intravenous infusion[1] |
藥物類別 | Neurosteroids; Antidepressants |
法律規範狀態 | |
法律規範 | |
藥物動力學數據 | |
血漿蛋白結合率 | >99%[1] |
藥物代謝 | Non-CYP450 (keto-reduction via AKRs, glucuronidation via UGTs, sulfation via SULTs)[1] |
生物半衰期 | 9 hours[1] |
排泄途徑 | Feces: 47%[1] Urine: 42%[1] |
識別資訊 | |
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CAS號 | 516-54-1 |
PubChem CID | |
DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
ChEBI | |
ChEMBL | |
CompTox Dashboard (EPA) | |
化學資訊 | |
化學式 | C21H34O2 |
摩爾質量 | 318.501 g/mol |
3D模型(JSmol) | |
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參考文獻
編輯- ^ 1.0 1.1 1.2 1.3 1.4 1.5 存档副本 (PDF). [2019-05-26]. (原始內容存檔 (PDF)於2020-11-12).
- ^ Reddy DS. Neurosteroids: endogenous role in the human brain and therapeutic potentials. Progress in Brain Research 186. 2010: 113–37. ISBN 9780444536303. PMC 3139029 . PMID 21094889. doi:10.1016/B978-0-444-53630-3.00008-7.
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被忽略 (幫助) - ^ 3.0 3.1 Commissioner, Office of the. Press Announcements - FDA approves first treatment for post-partum depression. www.fda.gov. [21 March 2019]. (原始內容存檔於2019-04-22) (英語).
- ^ Frieder A, Fersh M, Hainline R, Deligiannidis KM. Pharmacotherapy of Postpartum Depression: Current Approaches and Novel Drug Development. CNS Drugs. March 2019, 33 (3): 265–282. PMID 30790145. doi:10.1007/s40263-019-00605-7.
- ^ Wilkinson ST, Sanacora G. A new generation of antidepressants: an update on the pharmaceutical pipeline for novel and rapid-acting therapeutics in mood disorders based on glutamate/GABA neurotransmitter systems. Drug Discov. Today. February 2019, 24 (2): 606–615. PMID 30447328. doi:10.1016/j.drudis.2018.11.007.