十一烯酸睾酮

化合物

十一烯酸睾酮,縮寫TUe,是一種雄激素/合成代謝類固醇藥物和雄激素酯,已不再上市。[1][2][3]它是DurasteronTriolandren的成分,這兩種藥物是長效的睾酮酯油溶液混合物,通過肌肉注射給藥。[4][5][6][7]

十一烯酸睾酮
臨床資料
商品名英語Drug nomenclatureDurasteron、Triolandren
其他名稱TUe、睾酮十一烯酸酯
給藥途徑靜脈注射
藥物類別英語Drug class雄激素合成代謝類固醇雄激素酯
識別資訊
  • [(8R,9S,10R,13S,14S,17S)-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl] undec-10-enoate
CAS號29430-26-0  checkY
PubChem CID
ChemSpider
UNII
CompTox Dashboard英語CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.045.099 編輯維基數據鏈接
化學資訊
化學式C30H46O3
摩爾質量454.70 g·mol−1
3D模型(JSmol英語JSmol
  • C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2OC(=O)CCCCCCCCC=C)CCC4=CC(=O)CC[C@]34C
  • InChI=1S/C30H46O3/c1-4-5-6-7-8-9-10-11-12-28(32)33-27-16-15-25-24-14-13-22-21-23(31)17-19-29(22,2)26(24)18-20-30(25,27)3/h4,21,24-27H,1,5-20H2,2-3H3/t24-,25-,26-,27-,29-,30-/m0/s1
  • Key:PBFYIQCFOZXSKC-CNQKSJKFSA-N

參見

編輯

參考資料

編輯
  1. ^ Shapiro S, Weinburg K, Freedman L. Notes - Long-Acting Androgens. The Journal of Organic Chemistry. 1956, 21 (11): 1300–1302. ISSN 0022-3263. doi:10.1021/jo01117a602. 
  2. ^ Gould D, Finckenor L, Hershberg EB, Cassidy J, Perlman PL. Long-acting Testosterone Esters. Some Considerations on their Biological Utilization1. Journal of the American Chemical Society. 1957, 79 (16): 4472–4475. ISSN 0002-7863. doi:10.1021/ja01573a061. 
  3. ^ US 2855341,Meier, R; A Wettstein & E Lang,「Testosterone compositions」,發表於1958-10-07,指定於Ciba pharmaceutical Products, Inc. 
  4. ^ Schuermann H, Doepfmer R. Fertilitätsstörungen beim Manne. Springer-Verlag. 1960: 260–. ISBN 978-3-642-94784-1. 
  5. ^ Ufer J. Hormontherapie in der Frauenheilkunde: Grundlagen und Praxis. Gruyter. 1960: 153. ISBN 9783111138770. 
  6. ^ Aakvaag A, Vogt JH. Plasma testosterone values in different forms of testosterone treatment. Acta Endocrinologica. March 1969, 60 (3): 537–542. PMID 5395873. doi:10.1530/acta.0.0600537. Triolandren®, for intramuscular use, kindly supplied by Ciba, Basel, through Kobro 8c Co., Oslo, containing three different testosterone esters, in the following amounts of testosterone equivalents per ml oil: propionate 20 mg; valerate 80 mg; undecylenate 150 mg. 
  7. ^ Zachmann M, Prader A. Anabolic and androgenic effect of testosterone in sexually immature boys and its dependency on growth hormone. The Journal of Clinical Endocrinology and Metabolism. January 1970, 30 (1): 85–95. PMID 4311616. doi:10.1210/jcem-30-1-85. Triolandren, CIBA; 250 mg of this preparation contains 20 mg of testosterone propionate, 80 mg of testosterone-n-valerianate, and 150 mg of testosterone undecylenate—250 mg thus contains 173.8 mg of testosterone; the remaining 76.2 mg consists of the ester components [...]