甘草次酸
甘草次酸(glycyrrhetinic acid,或glycyrrhetic acid,也叫Enoxolone)是一種五環三萜物質,由草藥光果甘草的甘草酸水解得到故而得名。甘草次酸可以看作是β-香樹脂醇(齊墩果烷型)的衍生物,從而作為甘草酸的糖苷配基。甘草次酸常作為香料使用,也用來掩蓋蘆薈和奎寧等藥物的苦味。[1][2][3][4][5]
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臨床資料 | |
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商品名 | Arthrodont, PruClair |
AHFS/Drugs.com | 國際藥品名稱 |
給藥途徑 | Oral, topical |
ATC碼 | |
法律規範狀態 | |
法律規範 | |
識別資訊 | |
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CAS號 | 471-53-4 |
PubChem CID | |
ChemSpider | |
ChEBI | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.006.769 |
化學資訊 | |
化學式 | C30H46O4 |
摩爾質量 | 470.6838 |
3D模型(JSmol) | |
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另見
編輯參考文獻
編輯- ^ Chandler, RF. Liquorice, more than just a flavour. Canadian Pharmaceutical Journal. 1985, (118): 420–4.
- ^ Badam, L.; Amagaya, S.; Pollard, B. In vitro activity of licorice and glycyrrhetinic acid on Japanese encephalitis virus.. J. Community Dis. 1997, 29: 91–99.
- ^ Fuji, H.Y.; Tian, J.; Luka, C. Effect of glycyrrhetinic acid on influenza virus and pathogenic bacteria.. Bull. Chin. Mater. Med. 1986, 11: 238–241.
- ^ Guo, N.; Takechi, M.; Uno, C. Protective effect of glycyrrhizine in mice with systemic Candida albicans infection and its mechanism. J. Pharm. Pharmacol. 1991, 13 (5): 380–383. PMID 1839259.
- ^ Salari, M. H.; Sohrabi, N.; Kadkhoda, Z.; and Khalili, M. B.; capnophilic bacteria isolated from specimens of periodontitis patients. Antibacterial effects of Enoxolone on periodontopathogenic. Iran. Biomed. J. 2003, 7: 39–42.
延伸閱讀
編輯- Saponin Glycosides (頁面存檔備份,存於互聯網檔案館), by Georges-Louis Friedli, URL accessed Sept 2010.