CYP2C9

Cytochrome P450, family 2, subfamily C, polypeptide 9
Cytochrome P450, family 2, subfamily C, polypeptide 9
	CYP2C9的帶狀結構圖，中間可見血紅素基團。來自PDB 1OG2.
有效結構
PDB	直系同源檢索：PDBe, RCSB
PDB查詢代碼列表
	1OG2, 1OG5, 1R9O, 4NZ2
標識
代號	CYP2C9; CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9
擴展標識	遺傳學：601130 鼠基因：103238 同源基因：133566 ChEMBL: 3397 GeneCards: CYP2C9 Gene
EC編號	1.14.13.48, 1.14.13.49, 1.14.13.80
基因本體論描述
分子功能	· monooxygenase activity; · iron ion binding; · drug binding; · arachidonic acid epoxygenase activity; · steroid hydroxylase activity; · oxidoreductase activity; · oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; · (S)-limonene 6-monooxygenase activity; · (S)-limonene 7-monooxygenase activity; · oxygen binding; · heme binding; · caffeine oxidase activity; · (R)-limonene 6-monooxygenase activity;
細胞成分	· cytoplasm; · endoplasmic reticulum membrane; · intracellular membrane-bounded organelle;
生物過程	· xenobiotic metabolic process; · steroid metabolic process; · monoterpenoid metabolic process; · drug metabolic process; · arachidonic acid metabolic process; · epoxygenase P450 pathway; · urea metabolic process; · monocarboxylic acid metabolic process; · drug catabolic process; · exogenous drug catabolic process; · cellular amide metabolic process; · small molecule metabolic process; · oxidation-reduction process; · oxidative demethylation; · omega-hydroxylase P450 pathway;
	Sources: Amigo / QuickGO
RNA表達模式
	更多表達數據
直系同源體
物種	人類
Entrez	1559
Ensembl	ENSG00000138109
UniProt	P11712
mRNA序列	NM_000771
蛋白序列	NP_000762
基因位置	Chr 10:; 94.94 – 94.99 Mb
PubMed查詢	[1]
	閱; 論; 編;

細胞色素P450 2C9（英語：Cytochrome P450 2C9） （縮寫為CYP2C9）是一種由人類CYP2C9基因編碼的酶。^[1]^[2]

引用

^ Romkes M, Faletto MB, Blaisdell JA, Raucy JL, Goldstein JA. Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily. Biochemistry. Apr 1991, 30 (13): 3247–55. PMID 2009263. doi:10.1021/bi00227a012.
^ Inoue K, Inazawa J, Suzuki Y, Shimada T, Yamazaki H, Guengerich FP, Abe T. Fluorescence in situ hybridization analysis of chromosomal localization of three human cytochrome P450 2C genes (CYP2C8, 2C9, and 2C10) at 10q24.1. The Japanese Journal of Human Genetics. Sep 1994, 39 (3): 337–43. PMID 7841444. doi:10.1007/BF01874052.

[pmid2009263-1] Romkes M, Faletto MB, Blaisdell JA, Raucy JL, Goldstein JA. Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily. Biochemistry. Apr 1991, 30 (13): 3247–55. PMID 2009263. doi:10.1021/bi00227a012.

[pmid7841444-2] Inoue K, Inazawa J, Suzuki Y, Shimada T, Yamazaki H, Guengerich FP, Abe T. Fluorescence in situ hybridization analysis of chromosomal localization of three human cytochrome P450 2C genes (CYP2C8, 2C9, and 2C10) at 10q24.1. The Japanese Journal of Human Genetics. Sep 1994, 39 (3): 337–43. PMID 7841444. doi:10.1007/BF01874052.

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