CYP2C9

Cytochrome P450, family 2, subfamily C, polypeptide 9
Cytochrome P450, family 2, subfamily C, polypeptide 9
	CYP2C9的带状结构图，中间可见血红素基团。来自PDB 1OG2.
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	1OG2, 1OG5, 1R9O, 4NZ2
标识
代号	CYP2C9; CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9
扩展标识	遗传学：601130 鼠基因：103238 同源基因：133566 ChEMBL: 3397 GeneCards: CYP2C9 Gene
EC編號	1.14.13.48, 1.14.13.49, 1.14.13.80
基因本体论描述
分子功能	· monooxygenase activity; · iron ion binding; · drug binding; · arachidonic acid epoxygenase activity; · steroid hydroxylase activity; · oxidoreductase activity; · oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; · (S)-limonene 6-monooxygenase activity; · (S)-limonene 7-monooxygenase activity; · oxygen binding; · heme binding; · caffeine oxidase activity; · (R)-limonene 6-monooxygenase activity;
细胞成分	· cytoplasm; · endoplasmic reticulum membrane; · intracellular membrane-bounded organelle;
生物过程	· xenobiotic metabolic process; · steroid metabolic process; · monoterpenoid metabolic process; · drug metabolic process; · arachidonic acid metabolic process; · epoxygenase P450 pathway; · urea metabolic process; · monocarboxylic acid metabolic process; · drug catabolic process; · exogenous drug catabolic process; · cellular amide metabolic process; · small molecule metabolic process; · oxidation-reduction process; · oxidative demethylation; · omega-hydroxylase P450 pathway;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体
物种	人类
Entrez	1559
Ensembl	ENSG00000138109
UniProt	P11712
mRNA序列	NM_000771
蛋白序列	NP_000762
基因位置	Chr 10:; 94.94 – 94.99 Mb
PubMed查询	[1]
	查; 论; 编;

细胞色素P450 2C9（英語：Cytochrome P450 2C9） （缩写为CYP2C9）是一种由人类CYP2C9基因编码的酶。^[1]^[2]

引用

^ Romkes M, Faletto MB, Blaisdell JA, Raucy JL, Goldstein JA. Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily. Biochemistry. Apr 1991, 30 (13): 3247–55. PMID 2009263. doi:10.1021/bi00227a012.
^ Inoue K, Inazawa J, Suzuki Y, Shimada T, Yamazaki H, Guengerich FP, Abe T. Fluorescence in situ hybridization analysis of chromosomal localization of three human cytochrome P450 2C genes (CYP2C8, 2C9, and 2C10) at 10q24.1. The Japanese Journal of Human Genetics. Sep 1994, 39 (3): 337–43. PMID 7841444. doi:10.1007/BF01874052.

[pmid2009263-1] Romkes M, Faletto MB, Blaisdell JA, Raucy JL, Goldstein JA. Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily. Biochemistry. Apr 1991, 30 (13): 3247–55. PMID 2009263. doi:10.1021/bi00227a012.

[pmid7841444-2] Inoue K, Inazawa J, Suzuki Y, Shimada T, Yamazaki H, Guengerich FP, Abe T. Fluorescence in situ hybridization analysis of chromosomal localization of three human cytochrome P450 2C genes (CYP2C8, 2C9, and 2C10) at 10q24.1. The Japanese Journal of Human Genetics. Sep 1994, 39 (3): 337–43. PMID 7841444. doi:10.1007/BF01874052.

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