奥贝胆酸
化合物
奥贝胆酸(英语:Obeticholic acid,缩写OCA,也叫做6α-乙基-鹅去氧胆酸,6α-ethyl-chenodeoxycholic acid,商品名Ocaliva)是一种半合成胆汁酸,用于治疗原发性胆汁性胆管炎,后又用于治疗几种肝病。大日本住友制药拥有此药在中国和日本的所有权[2]。
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临床资料 | |
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商品名 | Ocaliva |
其他名称 | 6α-ethyl-chenodeoxycholic acid; INT-747 |
AHFS/Drugs.com | ocaliva |
MedlinePlus | a616033 |
核准状况 | |
给药途径 | 口服给药 |
ATC码 | |
法律规范状态 | |
法律规范 | |
识别信息 | |
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CAS号 | 459789-99-2 |
PubChem CID | |
IUPHAR/BPS | |
ChemSpider | |
UNII | |
KEGG | |
ChEBI | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.238.318 |
化学信息 | |
化学式 | C26H44O4 |
摩尔质量 | 420.62516 g/mol |
3D模型(JSmol) | |
熔点 | 108—110 °C(226—230 °F) [1] |
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参考文献
编辑- ^ Gioiello, Antimo; Macchiarulo, Antonio; Carotti, Andrea; Filipponi, Paolo; Costantino, Gabriele; Rizzo, Giovanni; Adorini, Luciano; Pellicciari, Roberto. Extending SAR of bile acids as FXR ligands: Discovery of 23-N-(carbocinnamyloxy)-3α,7α-dihydroxy-6α-ethyl-24-nor-5β-cholan-23-amine. Bioorganic & Medicinal Chemistry. April 2011, 19 (8): 2650–2658. PMID 21459580. doi:10.1016/j.bmc.2011.03.004.
- ^ Wall Street Journal. A $4 Billion Surprise for 45-Person Biotech. [10 January 2014]. (原始内容存档于2014-03-28).
外部链接
编辑- Intercept pharmaceuticals. [2019-07-03]. (原始内容存档于2014-01-10).
- NashBiotechs Several articles on drug candidates in NASH