奧貝膽酸

化合物

奧貝膽酸(英語:Obeticholic acid,縮寫OCA,也叫做6α-乙基-鵝去氧膽酸,6α-ethyl-chenodeoxycholic acid,商品名Ocaliva)是一種半合成膽汁酸,用於治療原發性膽汁性膽管炎,後又用於治療幾種肝病大日本住友製藥擁有此藥在中國和日本的所有權[2]

奧貝膽酸
臨床資料
商品名英語Drug nomenclatureOcaliva
其他名稱6α-ethyl-chenodeoxycholic acid; INT-747
AHFS/Drugs.comocaliva
MedlinePlusa616033
核准狀況
給藥途徑口服給藥
ATC碼
法律規範狀態
法律規範
識別資訊
  • (3α,5β,6α,7α)-6-Ethyl-3,7-dihydroxycholan-24-oic acid

    OR

    (4R)-4-[(3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
CAS號459789-99-2
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard英語CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.238.318 編輯維基數據鏈接
化學資訊
化學式C26H44O4
摩爾質量420.62516 g/mol
3D模型(JSmol英語JSmol
熔點108—110 °C(226—230 °F) [1]
  • CC[C@@H]1[C@@H]2C[C@@H](CC[C@@]2([C@H]3CC[C@]4([C@H]([C@@H]3[C@@H]1O)CC[C@@H]4[C@H](C)CCC(=O)O)C)C)O
  • InChI=1S/C26H44O4/c1-5-17-21-14-16(27)10-12-26(21,4)20-11-13-25(3)18(15(2)6-9-22(28)29)7-8-19(25)23(20)24(17)30/h15-21,23-24,27,30H,5-14H2,1-4H3,(H,28,29)/t15-,16-,17-,18-,19+,20+,21+,23+,24-,25-,26-/m1/s1
  • Key:ZXERDUOLZKYMJM-ZWECCWDJSA-N

參考文獻

編輯
  1. ^ Gioiello, Antimo; Macchiarulo, Antonio; Carotti, Andrea; Filipponi, Paolo; Costantino, Gabriele; Rizzo, Giovanni; Adorini, Luciano; Pellicciari, Roberto. Extending SAR of bile acids as FXR ligands: Discovery of 23-N-(carbocinnamyloxy)-3α,7α-dihydroxy-6α-ethyl-24-nor-5β-cholan-23-amine. Bioorganic & Medicinal Chemistry. April 2011, 19 (8): 2650–2658. PMID 21459580. doi:10.1016/j.bmc.2011.03.004. 
  2. ^ Wall Street Journal. A $4 Billion Surprise for 45-Person Biotech. [10 January 2014]. (原始內容存檔於2014-03-28). 

外部連結

編輯