α-乙醯-γ-丁內酯

Α-乙醯-γ-丁內酯
	IUPAC名; 3-acetyloxolan-2-one
英文名	2-Acetylbutyrolactone
別名	2-乙醯-γ-丁內酯
識別
縮寫	ABL
CAS編號	517-23-7
PubChem	10601
ChemSpider	10156
SMILES	CC(=O)C1CCOC1=O;
InChI	1S/C6H8O3/c1-4(7)5-2-3-9-6(5)8/h5H,2-3H2,1H3;
EINECS	208-235-2
ChEBI	179633
MeSH	2-acetylbutyrolactone
性質
化學式	C6H8O3
莫耳質量	128.13 g·mol−1
外觀	無色液體
密度	1.19 g/cm3
沸點	107-108 °C（380-381 K）（7 hPa）
溶解性	可溶於DMF和甲醇
危險性
	GHS危險性符號;
GHS提示詞	Warning
H-術語	H315, H319, H335
P-術語	P261, P271, P280, P302+352, P304+340, P305+351+338, P321, P362+364, P403+233, P405, P501
	若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。

ɑ-乙醯-γ-丁內酯（ABL）是γ-丁內酯的衍生物，可用於有機合成，也用於鑑定一級胺。^[2]

製備

ɑ-乙醯-γ-丁內酯可以由乙酸酯和γ-丁內酯在鹼溶液中發生縮合反應而成。^[5]

用處

螢光檢驗

ɑ-乙醯-γ-丁內酯本身的螢光很微弱，但它的衍生物照到紫外線時會發出很強的螢光。^[3]^[6]ɑ-乙醯-γ-丁內酯的羰基會和胺反應生成希夫鹼，因此經常用於在有機合成中確認合成出了胺。^[3]ɑ-乙醯-γ-丁內酯也可以和芳香胺發生雅普－克林格曼反應，生成螢光分子。^[6]

藥物的前體

ɑ-乙醯-γ-丁內酯是多種如檀香烯（德語：Santalene）^[7]的藥物的前體。

參考文獻

^ ^1.0 ^1.1 α-Acetylbutyrolactone Safety Data Sheet. SigmaAldrich. January 20, 2020 [March 30, 2022]. （原始內容存檔於2022-03-31）.
^ ^2.0 ^2.1 Sabry, Suzy M. Application of 2-acetylbutyrolactone to spectrofluorimetry: Fluorescence properties of Schiff bases derived from 2-acetylbutyrolactone and spectrofluorimetric determination of primary amine-containing compounds. Journal of Pharmaceutical and Biomedical Analysis. 2006, 40 (5): 1057–1067 [2022-06-12]. PMID 16256289. doi:10.1016/j.jpba.2005.08.036. （原始內容存檔於2018-06-27）（英語）.
^ ^3.0 ^3.1 ^3.2 Sabry, S M. Application of 2-acetylbutyrolactone to spectrofluorimetry: Fluorescence properties of Schiff bases derived from 2-acetylbutyrolactone and spectrofluorimetric determination of primary amine-containing compounds. Journal of Pharmaceutical and Biomedical Analysis. 2006, 40 (5): 1057–1067. PMID 16256289. doi:10.1016/j.jpba.2005.08.036.
^ 2-Acetylbutyrolactone. pubchem.ncbi.nlm.nih.gov. [31 March 2022]. （原始內容存檔於2022-08-29）（英語）.
^ Koehler, Guenther. Method for Preparing 2-Acetyl-y-Butyrolactone. United States Patent. August 4, 1998 [March 30, 2022]. （原始內容存檔於2022-03-31）.
^ ^6.0 ^6.1 Sabry, S M. Enhanced Spectrophotometry of Sulfonamides with Novel 2‐Acetylbutyrolactone Derivatives. Analytical Letters. 2006, 39 (13): 2591–2615. S2CID 93950011. doi:10.1080/00032710600824748.
^ Unnikrishnan, P,A. Syntheses of epi-β-Santalene, β-Santalene and an Isomer of β-Santalene with 4-Methyl-4-pentenyl Side Chain. Synthetic Communications. 1992, 22 (22): 3159–3168. doi:10.1080/00397919208021129.

[MSDS-1] 1.0 ^1.1 α-Acetylbutyrolactone Safety Data Sheet. SigmaAldrich. January 20, 2020 [March 30, 2022]. （原始內容存檔於2022-03-31）.

[Sabry-2] 2.0 ^2.1 Sabry, Suzy M. Application of 2-acetylbutyrolactone to spectrofluorimetry: Fluorescence properties of Schiff bases derived from 2-acetylbutyrolactone and spectrofluorimetric determination of primary amine-containing compounds. Journal of Pharmaceutical and Biomedical Analysis. 2006, 40 (5): 1057–1067 [2022-06-12]. PMID 16256289. doi:10.1016/j.jpba.2005.08.036. （原始內容存檔於2018-06-27）（英語）.

[:1-3] 3.0 ^3.1 ^3.2 Sabry, S M. Application of 2-acetylbutyrolactone to spectrofluorimetry: Fluorescence properties of Schiff bases derived from 2-acetylbutyrolactone and spectrofluorimetric determination of primary amine-containing compounds. Journal of Pharmaceutical and Biomedical Analysis. 2006, 40 (5): 1057–1067. PMID 16256289. doi:10.1016/j.jpba.2005.08.036.

[4] 2-Acetylbutyrolactone. pubchem.ncbi.nlm.nih.gov. [31 March 2022]. （原始內容存檔於2022-08-29）（英語）.

[Koehler-5] Koehler, Guenther. Method for Preparing 2-Acetyl-y-Butyrolactone. United States Patent. August 4, 1998 [March 30, 2022]. （原始內容存檔於2022-03-31）.

[:8-6] 6.0 ^6.1 Sabry, S M. Enhanced Spectrophotometry of Sulfonamides with Novel 2‐Acetylbutyrolactone Derivatives. Analytical Letters. 2006, 39 (13): 2591–2615. S2CID 93950011. doi:10.1080/00032710600824748.

[:5-7] Unnikrishnan, P,A. Syntheses of epi-β-Santalene, β-Santalene and an Isomer of β-Santalene with 4-Methyl-4-pentenyl Side Chain. Synthetic Communications. 1992, 22 (22): 3159–3168. doi:10.1080/00397919208021129.

[2]

[1]

[3]

[4]

[5]

[6]

[7]

Α-乙醯-γ-丁內酯

IUPAC名 3-acetyloxolan-2-one
英文名	2-Acetylbutyrolactone
別名	2-乙醯-γ-丁內酯
識別
縮寫	ABL
CAS編號	517-23-7 ^Y
PubChem	10601
ChemSpider	10156
SMILES	CC(=O)C1CCOC1=O
InChI	1S/C6H8O3/c1-4(7)5-2-3-9-6(5)8/h5H,2-3H2,1H3
EINECS	208-235-2
ChEBI	179633
MeSH	2-acetylbutyrolactone
性質
化學式	C₆H₈O₃
莫耳質量	128.13 g·mol⁻¹
外觀	無色液體
密度	1.19 g/cm³ ^[1]
沸點	107-108 °C（380-381 K）（7 hPa^[1]）
溶解性	可溶於DMF^[2]和甲醇^[3]
危險性
GHS危險性符號 ^[4]
GHS提示詞	Warning
H-術語	H315, H319, H335
P-術語	P261, P271, P280, P302+352, P304+340, P305+351+338, P321, P362+364, P403+233, P405, P501
若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。