雄激素受體
雄激素受體(英語:androgen receptor,簡稱為AR),亦被稱為NR3C4(核受體亞家族3,C組,成員4)是一類核受體[6],當雄性激素睪酮或二氫睪酮[7]在細胞質中與之結合後會使之激活繼而轉運進核內。雄激素受體與孕酮受體之間的關係很密切,高劑量的黃體製劑可阻斷雄激素受體[8][9]。
雄激素受體 | |||||||||
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![]() 人類雄激素受體結合配體的結構域正與雄激素結合的晶體結構,受體NH2-端肽鏈、ar20-30及r1881 | |||||||||
鑑定 | |||||||||
標誌 | Androgen_recep | ||||||||
Pfam | PF02166(舊版) | ||||||||
InterPro | IPR001103 | ||||||||
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![](http://upload.wikimedia.org/wikipedia/commons/thumb/8/81/Human_androgen_receptor_and_androgen_binding_%28zh-cn%29.svg/294px-Human_androgen_receptor_and_androgen_binding_%28zh-cn%29.svg.png)
雄激素受體的主要功能是作為調控基因表達的一種結合DNA的轉錄因子[10];然而雄激素受體也有其它方面的功能[11]。受雄激素調控的基因在男性性表型的發育及維持中起到重要作用。
另見
編輯參考文獻
編輯- ^ PDB 2AM9; Pereira de Jésus-Tran K, Côté PL, Cantin L, Blanchet J, Labrie F, Breton R. Comparison of crystal structures of human androgen receptor ligand-binding domain complexed with various agonists reveals molecular determinants responsible for binding affinity. Protein Sci. May 2006, 15 (5): 987–99. PMC 2242507 . PMID 16641486. doi:10.1110/ps.051905906.
- ^ Quigley CA, De Bellis A, Marschke KB, el-Awady MK, Wilson EM, French FS. Androgen receptor defects: historical, clinical, and molecular perspectives. Endocr. Rev. June 1995, 16 (3): 271–321. PMID 7671849. doi:10.1210/edrv-16-3-271.
- ^ Gottlieb B, Lombroso R, Beitel LK, Trifiro MA. Molecular pathology of the androgen receptor in male (in)fertility. Reprod. Biomed. Online. January 2005, 10 (1): 42–8. PMID 15705293. doi:10.1016/S1472-6483(10)60802-4.
- ^ Choong CS, Wilson EM. Trinucleotide repeats in the human androgen receptor: a molecular basis for disease. J. Mol. Endocrinol. December 1998, 21 (3): 235–57. PMID 9845666. doi:10.1677/jme.0.0210235.
- ^ Meehan KL, Sadar MD. Androgens and androgen receptor in prostate and ovarian malignancies. Front. Biosci. May 2003, 8: d780–800. PMID 12700055. doi:10.2741/1063.
- ^ Lu NZ, Wardell SE, Burnstein KL, Defranco D, Fuller PJ, Giguere V, Hochberg RB, McKay L, Renoir JM, Weigel NL, Wilson EM, McDonnell DP, Cidlowski JA. International Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors. Pharmacol. Rev. December 2006, 58 (4): 782–97. PMID 17132855. doi:10.1124/pr.58.4.9.
- ^ Roy AK, Lavrovsky Y, Song CS, Chen S, Jung MH, Velu NK, Bi BY, Chatterjee B. Regulation of androgen action. Vitam. Horm. Vitamins & Hormones. 1999, 55: 309–52. ISBN 978-0-12-709855-5. PMID 9949684. doi:10.1016/S0083-6729(08)60938-3.
- ^ Bardin CW, Brown T, Isomaa VV, Jänne OA. Progestins can mimic, inhibit and potentiate the actions of androgens. Pharmacol. Ther. 1983, 23 (3): 443–59. PMID 6371845. doi:10.1016/0163-7258(83)90023-2.
- ^ Raudrant D, Rabe T. Progestogens with antiandrogenic properties. Drugs. 2003, 63 (5): 463–92. PMID 12600226. doi:10.2165/00003495-200363050-00003.[永久失效連結]
- ^ Mooradian AD, Morley JE, Korenman SG. Biological actions of androgens. Endocr. Rev. 1987, 8 (1): 1–28. PMID 3549275. doi:10.1210/edrv-8-1-1.
- ^ Heinlein CA, Chang C. The roles of androgen receptors and androgen-binding proteins in nongenomic androgen actions. Mol. Endocrinol. 2002, 16 (10): 2181–7. PMID 12351684. doi:10.1210/me.2002-0070.
外部連結
編輯- GeneReviews/NCBI/NIH/UW entry on Androgen Insensitivity Syndrome (頁面存檔備份,存於網際網路檔案館)
- OMIM entries on Androgen Insensitivity Syndrome
- GeneReviews/NIH/NCBI/UW entry on Spinal and Bulbar Muscular Atrophy, Kennedy's Disease, SBMA, X-Linked Spinal and Bulbar Muscular Atrophy (頁面存檔備份,存於網際網路檔案館)
- OMIM entries on Spinal and Bulbar Muscular Atrophy, Kennedy's Disease, SBMA, X-Linked Spinal and Bulbar Muscular Atrophy
- 醫學主題詞表(MeSH):Androgen+Receptors
- Brinkmann AO. Androgen physiology: receptor and metabolic disorders (PDF). Robert McLachlan, editor (編). Endocrinology of Male Reproduction. Endotext.org. [2008-04-29]. (原始內容 (PDF)存檔於2012-02-22).
- Gottlieb B. The Androgen Receptor Gene Mutations Database Server. McGill University. 2007-07-24 [2008-04-29]. (原始內容存檔於2008-04-22).
- Thompson J. Molecular Mechanisms of Androgen Receptor Interactions (PDF). Helsinki University Biomedical Dissertations No. 80. University of Helsinki. 2006-09-30 [2008-04-29]. (原始內容 (PDF)存檔於2008-04-06).