妊娠相关血浆蛋白A

妊娠相关血浆蛋白A(英語:pregnancy-associated plasma protein A,或Pappalysin-1,缩写PAPP-A)是一种由人类基因 PAPPA 编码的蛋白质,PAPP-A是一种分泌蛋白酶,其主要底物是胰岛素样生长因子结合蛋白。PAPP-A也用于唐氏综合征的筛查试验。[5][6]

妊娠相关血浆蛋白A
識別號
别名PAPPA;, ASBABP2, DIPLA1, IGFBP-4ase, PAPA, PAPP-A, PAPPA1, pappalysin 1
外部IDOMIM176385 MGI97479 HomoloGene31097 GeneCardsPAPPA
基因位置(人类
9號染色體
染色体9號染色體[1]
9號染色體
妊娠相关血浆蛋白A的基因位置
妊娠相关血浆蛋白A的基因位置
基因座9q33.1起始116,153,791 bp[1]
终止116,402,321 bp[1]
RNA表达模式


查阅更多表达数据
直系同源
物種人類小鼠
Entrez
Ensembl
UniProt
mRNA​序列

​NM_002581

NM_021362

蛋白序列

NP_002572

NP_067337

基因位置​(UCSC)Chr 9: 116.15 – 116.4 MbChr 4: 65.04 – 65.28 Mb
PubMed​查找[3][4]
維基數據
檢視/編輯人類檢視/編輯小鼠

功能

编辑

基因编码一种分泌的金属蛋白酶,主要用于切割胰岛素样生长因子的结合蛋白(IGFBPs)。PAPP-A的蛋白水解活性在与膠原蛋白结合后被激活,参与许多局部增生过程,比如傷口癒合重塑。血浆中出现低水平的此蛋白被认为是妊娠中出现非整倍體胎兒(胎兒拥有不正常的染色体数)的生化标志物[6],比如在唐氏综合征產前診斷中,低水平的PAPP-A是一个重要标志[5]。低水平的PAPP-A也可表明胎盤存在问题,并导致不良并发症如宫内生长受限妊娠毒血症胎盤早期剝離早產乃至死產

相互作用

编辑

妊娠相关血浆蛋白A已知可与主要碱性蛋白发生蛋白質交互作用[7][8][9]

参考文献

编辑
  1. ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000182752 - Ensembl, May 2017
  2. ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000028370 - Ensembl, May 2017
  3. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  4. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ 5.0 5.1 Breathnach FM, Malone FD. Screening for aneuploidy in first and second trimesters: is there an optimal paradigm?. Curr. Opin. Obstet. Gynecol. 2007, 19 (2): 176–82. PMID 17353686. doi:10.1097/GCO.0b013e3280895e00. 
  6. ^ 6.0 6.1 Entrez Gene: PAPPA pregnancy-associated plasma protein A, pappalysin 1. 
  7. ^ Overgaard MT, Haaning J, Boldt HB, Olsen IM, Laursen LS, Christiansen M, Gleich GJ, Sottrup-Jensen L, Conover CA, Oxvig C. Expression of recombinant human pregnancy-associated plasma protein-A and identification of the proform of eosinophil major basic protein as its physiological inhibitor. J. Biol. Chem. October 2000, 275 (40): 31128–33. PMID 10913121. doi:10.1074/jbc.M001384200. 
  8. ^ Overgaard MT, Sorensen ES, Stachowiak D, Boldt HB, Kristensen L, Sottrup-Jensen L, Oxvig C. Complex of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein. Disulfide structure and carbohydrate attachment. J. Biol. Chem. January 2003, 278 (4): 2106–17. PMID 12421832. doi:10.1074/jbc.M208777200. 
  9. ^ Oxvig C, Sand O, Kristensen T, Gleich GJ, Sottrup-Jensen L. Circulating human pregnancy-associated plasma protein-A is disulfide-bridged to the proform of eosinophil major basic protein. J. Biol. Chem. June 1993, 268 (17): 12243–6. PMID 7685339. 

延伸阅读

编辑

外部链接

编辑
  • The MEROPS online database for peptidases and their inhibitors: M43.004