孕三烯酮
孕三烯酮(英語:Gestrinone)是一种用于治疗子宮內膜異位症的药物[2][3],也用于治疗子宮肌瘤、經血過多以及进行生育控制[1]。孕三烯酮通常单独使用,不与其他药物联合使用[4],可由口服给药或阴道内给药[1]。
臨床資料 | |
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商品名 | Dimetriose, Dimetrose, Nemestran, others |
其他名稱 | Ethylnorgestrienone; A-46745; R2323; R-2323; RU-2323; 17α-Ethynyl-18-methyl-δ9,11-19-nortestosterone; 17α-Ethynyl-18-methylestra-4,9,11-trien-17β-ol-3-one; 13β-Ethyl-18,19-dinor-17α-pregna-4,9,11-trien-20-yn-17β-ol-3-one |
AHFS/Drugs.com | 国际药品名称 |
懷孕分級 |
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给药途径 | By mouth, vaginal[1] |
藥物類別 | Progestin; Progestogen; Antiprogestogen; Androgen; Anabolic steroid; Steroidogenesis inhibitor; Antiestrogen |
ATC碼 | |
藥物動力學數據 | |
血漿蛋白結合率 | To albumin[1] |
药物代谢 | Liver (hydroxylation)[1] |
生物半衰期 | 27.3 hours[1] |
排泄途徑 | Urine and bile[1] |
识别信息 | |
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CAS号 | 16320-04-0 |
PubChem CID | |
DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
ChEBI | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.210.606 |
化学信息 | |
化学式 | C21H24O2 |
摩尔质量 | 308.41 g/mol |
3D模型(JSmol) | |
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参考文献
编辑- ^ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Eric J. Thomas; John Rock. Modern Approaches to Endometriosis. Springer Science & Business Media. 6 December 2012: 228, 232, 234. ISBN 978-94-011-3864-2.
- ^ Coutinho EM. Therapeutic experience with gestrinone. Prog. Clin. Biol. Res. 1990, 323: 233–40. PMID 2406749.
- ^ Dr. Ian Morton; I.K. Morton; Judith M. Hall. Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. 31 October 1999: 132–. ISBN 978-0-7514-0499-9.
- ^ 引用错误:没有为名为
Drugs.com
的参考文献提供内容
延伸阅读
编辑- Coutinho E, Gonçalves MT, Azadian-Boulanger G, Silva AR. Endometriosis therapy with gestrinone by oral, vaginal or parenteral administration. Contrib Gynecol Obstet. 1987, 16: 227–35. PMID 3691096. doi:10.1159/000414891 (不活跃 2018-10-13).
- Coutinho EM. Therapeutic experience with gestrinone. Prog. Clin. Biol. Res. 1990, 323: 233–40. PMID 2406749.