孕三烯酮(英語:Gestrinone)是一种用于治疗子宮內膜異位症的药物[2][3],也用于治疗子宮肌瘤經血過多以及进行生育控制[1]。孕三烯酮通常单独使用,不与其他药物联合使用[4],可由口服给药阴道内给药[1]

孕三烯酮
臨床資料
商品名英语Drug nomenclatureDimetriose, Dimetrose, Nemestran, others
其他名稱Ethylnorgestrienone; A-46745; R2323; R-2323; RU-2323; 17α-Ethynyl-18-methyl-δ9,11-19-nortestosterone; 17α-Ethynyl-18-methylestra-4,9,11-trien-17β-ol-3-one; 13β-Ethyl-18,19-dinor-17α-pregna-4,9,11-trien-20-yn-17β-ol-3-one
AHFS/Drugs.com国际药品名称
懷孕分級
  • X
给药途径By mouth, vaginal[1]
藥物類別英语Drug classProgestin; Progestogen; Antiprogestogen; Androgen; Anabolic steroid; Steroidogenesis inhibitor; Antiestrogen
ATC碼
藥物動力學數據
血漿蛋白結合率To albumin[1]
药物代谢Liver (hydroxylation)[1]
生物半衰期27.3 hours[1]
排泄途徑Urine and bile[1]
识别信息
  • (8S,13S,14S,17R)-13-ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
CAS号16320-04-0  checkY
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.210.606 編輯維基數據鏈接
化学信息
化学式C21H24O2
摩尔质量308.41 g/mol
3D模型(JSmol英语JSmol
  • O=C4\C=C3/C(=C2/C=C\[C@]1([C@@H](CC[C@]1(C#C)O)[C@@H]2CC3)CC)CC4
  • InChI=1S/C21H24O2/c1-3-20-11-9-17-16-8-6-15(22)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h2,9,11,13,18-19,23H,3,5-8,10,12H2,1H3/t18-,19+,20+,21+/m1/s1 checkY
  • Key:BJJXHLWLUDYTGC-ANULTFPQSA-N checkY

参考文献

编辑
  1. ^ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Eric J. Thomas; John Rock. Modern Approaches to Endometriosis. Springer Science & Business Media. 6 December 2012: 228, 232, 234. ISBN 978-94-011-3864-2. 
  2. ^ Coutinho EM. Therapeutic experience with gestrinone. Prog. Clin. Biol. Res. 1990, 323: 233–40. PMID 2406749. 
  3. ^ Dr. Ian Morton; I.K. Morton; Judith M. Hall. Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. 31 October 1999: 132–. ISBN 978-0-7514-0499-9. 
  4. ^ 引用错误:没有为名为Drugs.com的参考文献提供内容

延伸阅读

编辑
  • Coutinho E, Gonçalves MT, Azadian-Boulanger G, Silva AR. Endometriosis therapy with gestrinone by oral, vaginal or parenteral administration. Contrib Gynecol Obstet. 1987, 16: 227–35. PMID 3691096. doi:10.1159/000414891 (不活跃 2018-10-13). 
  • Coutinho EM. Therapeutic experience with gestrinone. Prog. Clin. Biol. Res. 1990, 323: 233–40. PMID 2406749.