氟地西泮
化合物
氟地西泮(Fludiazepam)是由羅氏藥廠(Hoffman-LaRoche)在20世紀60年代所開發的一種苯二氮平類藥物之衍生藥物,和地西泮有密切關聯[1][2]。在日本商品名(Erispan)、在台灣商品名 「癒利舒盼錠」(Erispan)、福安源錠(Flupine),用0.25毫克的片劑裝來銷售[3][4]。
臨床資料 | |
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AHFS/Drugs.com | 国际药品名称 |
懷孕分級 |
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给药途径 | Oral |
ATC碼 | |
法律規範狀態 | |
法律規範 |
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藥物動力學數據 | |
生物利用度 | ? |
药物代谢 | 肝臟 |
生物半衰期 | ? |
排泄途徑 | 腎 |
识别信息 | |
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CAS号 | 3900-31-0 |
PubChem CID | |
DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
ChEBI | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.292.343 |
化学信息 | |
化学式 | C16H12ClFN2O |
摩尔质量 | 302.7 |
3D模型(JSmol) | |
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氟地西泮通過增強GABA的抑制性來發揮其藥理特性[5],且氟地西泮對苯二氮卓受體(benzodiazepine receptor)比起對地西泮來有四倍多的結合親和力[6]。它具有抗焦慮[7][8][9]、抗驚厥、鎮靜、催眠及骨骼肌鬆弛等特性[10]。不過,氟地西泮有藥物濫用的潛在趨勢[11],在多個國家列為管制藥品。
註釋
编辑- ^ US Patent 3299053 -ARYL-JH-L,X-BENZODIAZEPIN-Z(LH)-ONES
- ^ Neville, GA.; Beckstead, HD.; Shurvell, HF. A Fourier transform-Raman and infrared vibrational study of delorazepam, fludiazepam, flurazepam, and tetrazepam.. J Pharm Sci. Feb 1994, 83 (2): 143–51. PMID 7909552. doi:10.1002/jps.2600830207.
- ^ Su, TP.; Chen, TJ.; Hwang, SJ.; Chou, LF.; Fan, AP.; Chen, YC. Utilization of psychotropic drugs in Taiwan: an overview of outpatient sector in 2000.. Zhonghua Yi Xue Za Zhi (Taipei). Aug 2002, 65 (8): 378–91. PMID 12455808.
- ^ Benzodiazepine Names. non-benzodiazepines.org.uk. [2008-12-29]. (原始内容存档于2008-12-08).
- ^ Tsuchiya, T.; Fukushima, H. Effects of benzodiazepines and pentobarbitone on the gaba-ergic recurrent inhibition of hippocampal neurons.. Eur J Pharmacol. Apr 1978, 48 (4): 421–4. PMID 648585. doi:10.1016/0014-2999(78)90169-3.
- ^ Nakatsuka, I.; Shimizu, H.; Asami, Y.; Katoh, T.; Hirose, A.; Yoshitake, A. Benzodiazepines and their metabolites: relationship between binding affinity to the benzodiazepine receptor and pharmacological activity.. Life Sci. Jan 1985, 36 (2): 113–9. PMID 2857046. doi:10.1016/0024-3205(85)90089-X.
- ^ Okada, S.; Ichiki, K.; Tanokuchi, S.; Ishii, K.; Hamada, H.; Ota, Z. Effect of an anxiolytic on lipid profile in non-insulin-dependent diabetes mellitus.. J Int Med Res. 1994, 22 (6): 338–42. PMID 7895897.
- ^ Okada, S.; Ichiki, K.; Tanokuchi, S.; Ishii, K.; Hamada, H.; Ota, Z. Improvement of stress reduces glycosylated haemoglobin levels in patients with type 2 diabetes.. J Int Med Res. 1995, 23 (2): 119–22. PMID 7601294.
- ^ Okada, S.; Ichiki, K.; Tanokuchi, S.; Ishii, K.; Hamada, H.; Ota, Z. How blood pressure in patients with non-insulin-dependent diabetes mellitus is influenced by stress.. J Int Med Res. 1995, 23 (5): 377–80. PMID 8529781.
- ^ Inoue, H.; Maeno, Y.; Iwasa, M.; Matoba, R.; Nagao, M. Screening and determination of benzodiazepines in whole blood using solid-phase extraction and gas chromatography/mass spectrometry.. Forensic Sci Int. Sep 2000, 113 (1-3): 367–73. PMID 10978650. doi:10.1016/S0379-0738(00)00226-7.
- ^ Shimamine, M.; Masunari, T.; Nakahara, Y. [Studies on identification of drugs of abuse by diode array detection. I. Screening-test and identification of benzodiazepines by HPLC-DAD with ICOS software system]. Eisei Shikenjo Hokoku. 1993, (111): 47–56. PMID 7920567.
參見
编辑外部連結
编辑- (日語) Erispan フルジアゼパム錠,細粒[永久失效連結] (PDF) Dainippon Sumitomo Pharma. November 2005.
- (日語) Official Dainippon Sumitomo Pharma Website (页面存档备份,存于互联网档案馆)