7-羟基帽柱木碱

化合物

7-羟基帽柱木碱(英語:7-Hydroxymitragynine,缩写7-OH)是一种有机化合物,分子式C23H30N2O5,属于萜类吲哚生物碱,存在于卡痛树Mitragyna speciosa)等植物中[2]

7-Hydroxymitragynine
臨床資料
其他名稱7α-Hydroxy-7H-mitragynine;[1] 9-Methoxycorynantheidine hydroxyindolenine[1]
给药途径口服给药
藥物類別英语Drug classOpioid
ATC碼
  • 未分配
法律規範狀態
法律規範
  • 未列入管制
藥物動力學數據
代謝產物Mitragynine pseudoindoxyl
识别信息
  • Methyl (2E)-2-[(2S,3S,7aS,12bS)-3-ethyl-7a-hydroxy-8-methoxy-1,2,3,4,6,7,7a,12b-octahydroindolo[2,3-a]quinolizin-2-yl]-3-methoxyprop-2-enoate
CAS号174418-82-7  ☒N
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
化学信息
化学式C23H30N2O5
摩尔质量414.50 g·mol−1
3D模型(JSmol英语JSmol
  • CC[C@@H]1CN2CC[C@@]3(O)C(=Nc4cccc(OC)c34)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC

  • CC[C@@H]1CN2CC[C@@]3(O)C(=NC4=CC=CC(OC)=C34)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC
  • InChI=1S/C23H30N2O5/c1-5-14-12-25-10-9-23(27)20-17(7-6-8-19(20)29-3)24-21(23)18(25)11-15(14)16(13-28-2)22(26)30-4/h6-8,13-15,18,27H,5,9-12H2,1-4H3/b16-13+/t14-,15+,18+,23+/m1/s1 checkY
  • Key:RYENLSMHLCNXJT-CYXFISRXSA-N checkY

参考文献

编辑
  1. ^ 1.0 1.1 Chemical Abstracts Service: Columbus, OH, 2004; RN 174418-82-7 (accessed via SciFinder Scholar, version 2007.3; November 30, 2011)
  2. ^ Matsumoto K, Horie S, Ishikawa H, Takayama H, Aimi N, Ponglux D, Watanabe K. Antinociceptive effect of 7-hydroxymitragynine in mice: Discovery of an orally active opioid analgesic from the Thai medicinal herb Mitragyna speciosa. Life Sciences. March 2004, 74 (17): 2143–2155. PMID 14969718. doi:10.1016/j.lfs.2003.09.054.