JWH大麻素列表
维基媒体列表条目
克莱门森大学的约翰·威廉·霍夫曼(John William Huffman)研究小组合成了450多种大麻素[1][2]。其中一些是[3][4]:
001—100
编辑名称 | 类别 | 分子式 | Ki/nM (CB1) | Ki/nM (CB2) | 选择性 | 结构 | CAS编号 |
---|---|---|---|---|---|---|---|
JWH-004 | 萘甲酰基吲哚 | C26H27NO | 48 ± 13 | 4 ± 1.5 | CB2 (12x) | 155471-11-7 | |
JWH-007[5] | 萘甲酰基吲哚 | C25H25NO | 9.5 ± 4.5 | 2.9 ± 2.6 | CB2 (3.3x) | 155471-10-6 | |
JWH-009 | 萘甲酰基吲哚 | C27H29NO | >10000 | 141 ± 14 | CB2 (>70x) | 155471-12-8 | |
JWH-011 | 萘甲酰基吲哚 | C27H29NO | 155471-13-9 | ||||
JWH-015[5] | 萘甲酰基吲哚 | C23H21NO | 164 ± 22 | 13.8 ± 4.6 | CB2 (12x) | 155471-08-2 | |
JWH-016 | 萘甲酰基吲哚 | C24H23NO | 22 ± 1.5 | 4.3 ± 1.6 | CB2 (5.1x) | 155471-09-3 | |
JWH-018[5] | 萘甲酰基吲哚 | C24H23NO | 9 ± 5 | 2.9 ± 2.6 | CB2 (3.1x) | 209414-07-3 | |
JWH-019 | 萘甲酰基吲哚 | C25H25NO | 9.8 ± 2 | 5.55 ± 2 | CB2 (1.77x) | 209414-08-4 | |
JWH-020 | 萘甲酰基吲哚 | C26H27NO | 128 ± 17 | 205 ± 20 | CB1 (1.6x) | 209414-09-5 | |
JWH-030 | 萘甲酰基吡咯 | C20H21NO | 87 ± 3 | 320 ± 127 | CB1 (3.7x) | 162934-73-8 | |
JWH-031 | 萘甲酰基吡咯 | C21H23NO | 399 ± 109 | 162934-74-9 | |||
JWH-032 | 萘甲酰基吡咯 | C18H17NO | >10000 | >10000 | — | 162934-71-6 | |
JWH-033 | 萘甲酰基吡咯 | C19H19NO | 666 ± 77 | 162934-72-7 | |||
JWH-036 | 萘甲酰基吡咯 | C22H25NO | 309 ± 11 | 162934-75-0 | |||
JWH-042[6] | 萘甲酰基吲哚 | C21H17NO | >10000 | 5050 ± 192 | CB2 | 209414-02-8 | |
JWH-043[6] | 萘甲酰基吲哚 | C22H19NO | 1180 ± 44 | 964 ± 242 | CB2 (1.2x) | 209414-03-9 | |
JWH-044 | 萘甲酰基吡咯 | C16H13NO | >10000 | >10000 | — | 209414-10-8 | |
JWH-045 | 萘甲酰基吡咯 | C17H15NO | >10000 | >10000 | — | 209414-11-9 | |
JWH-046[6] | 萘甲酰基吲哚 | C24H23NO | 343 ± 38 | 16.3 ± 4.9 | CB2 (21x) | 316189-64-7 | |
JWH-047[6] | 萘甲酰基吲哚 | C25H25NO | 59 ± 3 | 3.47 ± 1.80 | CB2 (17x) | 316189-65-8 | |
JWH-048[6] | 萘甲酰基吲哚 | C26H27NO | 10.7 ± 1.0 | 0.49 ± 0.13 | CB2 (22x) | 316189-66-9 | |
JWH-049[6] | 萘甲酰基吲哚 | C27H29NO | 55.1 ± 17.0 | 32.3 ± 2.4 | CB2 (1.7x) | 316189-67-0 | |
JWH-050[6] | 萘甲酰基吲哚 | C28H31NO | 342 ± 6 | 526 ± 133 | CB1 (1.5x) | 1348257-03-3 | |
JWH-051 | 二苯并吡喃 | C25H38O2 | 1.20 | 0.03 | CB2 (40x) | 181764-31-8 | |
JWH-056[7] | 二苯并吡喃 | C21H30O | >10000 | 32 ± 9 | CB2 | 60856-72-6 | |
JWH-057[8] | 二苯并吡喃 | C25H38O | 23 ± 7 | 2.9 ± 1.6 | CB2 (8x) | 105823-04-9 | |
JWH-065[7] | 二苯并吡喃 | C23H34O | 399 ± 76 | 10 ± 2 | CB2 (40x) | 259869-56-2 | |
JWH-070[6] | 萘甲酰基吲哚 | C20H15NO | >10000 | >10000 | 209414-04-0 | ||
JWH-071[6] | 萘甲酰基吲哚 | C21H17NO | 1340 ± 123 | 2940 ± 852 | CB1 (2.2x) | 209414-05-1 | |
JWH-072 | 萘甲酰基吲哚 | C22H19NO | 1050 ± 5.5 | 170 ± 54 | CB2 (6x) | 209414-06-2 | |
JWH-073 | 萘甲酰基吲哚 | C23H21NO | 8.9 ± 1.8 | 27 ± 12 | CB1 (3x) | 208987-48-8 | |
JWH-076[5] | 萘甲酰基吲哚 | C23H21NO | 214 ± 11 | 106 ± 46 | CB2 (2x) | 824960-09-0 | |
JWH-077[6] | 萘甲酰基吲哚 | C21H17NO2 | >10000 | >10000 | 210179-35-4 | ||
JWH-078[6] | 萘甲酰基吲哚 | C22H19NO2 | 817 ± 60 | 633 ± 116 | CB2 (1.3x) | 210179-37-6 | |
JWH-079[6] | 萘甲酰基吲哚 | C23H21NO2 | 63.0 ± 3.0 | 32.0 ± 6.0 | CB2 (2x) | 210179-40-1 | |
JWH-080[6] | 萘甲酰基吲哚 | C24H23NO2 | 8.9 ± 1.8 | 2.21 ± 1.30 | CB2 (4x) | 210179-44-5 | |
JWH-081[6] | 萘甲酰基吲哚 | C25H25NO2 | 1.2 ± 0.03 | 12.4 ± 2.2 | CB1 (10x) | 210179-46-7 | |
JWH-082[6] | 萘甲酰基吲哚 | C26H27NO2 | 5.3 ± 0.8 | 6.40 ± 0.94 | CB1 (1.2x) | 210179-48-9 | |
JWH-083[6] | 萘甲酰基吲哚 | C27H29NO2 | 106 ± 12 | 102 ± 50 | — | 316189-69-2 | |
JWH-091[9] (Δ8-THCP) | 二苯并吡喃 | C23H34O2 | 22.0 ± 3.9 | 54763-99-4 | |||
JWH-093[6] | 萘甲酰基吲哚 | C27H29NO2 | 40.7 ± 2.8 | 59.1 ± 10.5 | CB1 (1.45x) | 316189-71-6 | |
JWH-094[6] | 萘甲酰基吲哚 | C24H23NO2 | 476 ± 67 | 97.3 ± 2.7 | CB2 (4.9x) | 316189-70-5 | |
JWH-095[6] | 萘甲酰基吲哚 | C29H33NO2 | 140 ± 4.3 | 312 ± 83 | CB1 (2.2x) | 316189-73-8 | |
JWH-096[6] | 萘甲酰基吲哚 | C25H25NO2 | 33.7 ± 2.9 | 13.3 ± 5.6 | CB2 (2.5x) | 316189-72-7 | |
JWH-097[6] | 萘甲酰基吲哚 | C31H37NO2 | 455 ± 28 | 121 ± 15 | CB2 (3.8x) | 316189-75-0 | |
JWH-098[6] | 萘甲酰基吲哚 | C26H27NO2 | 4.5 ± 0.1 | 1.9 ± 0.3 | CB2 (2.4x) | 316189-74-9 | |
JWH-099[6] | 萘甲酰基吲哚 | C27H29NO2 | 35.3 ± 9.0 | 17.8 ± 2.9 | CB2 (2x) | 316189-76-1 | |
JWH-100[6] | 萘甲酰基吲哚 | C28H31NO2 | 381 ± 102 | 155 ± 74 | CB2 (2.5x) | 316189-77-2 |
101—200
编辑名称 | 类别 | 分子式 | Ki/nM (CB1) | Ki/nM (CB2) | 选择性 | 结构 | CAS编号 |
---|---|---|---|---|---|---|---|
JWH-102[7] | 二苯并吡喃 | C24H38O2 | 7.9 ± 0.9 | 5.2 ± 2.0 | CB2 (1.5x) | 259869-52-8 | |
JWH-103[7] | 二苯并吡喃 | C24H38O2 | 28 ± 3 | 23 ± 7 | CB2 (1.2x) | 259869-53-9 | |
JWH-116[10] | 萘甲酰基吲哚 | C26H27NO | 52 ± 5 | 619294-64-3 | |||
JWH-120[5] | 萘甲酰基吲哚 | C23H21NO | 1054 ± 31 | 6.1 ± 0.7 | CB2 (173x) | 824955-98-8 | |
JWH-121[來源請求] | 萘甲酰基吲哚 | C24H23NO | — | 1354631-21-2 | |||
JWH-122[10] | 萘甲酰基吲哚 | C25H25NO | 0.69 ± 0.05 | 1.2 ± 1.2 | — | 619294-47-2 | |
JWH-124 (Δ8-Parahexyl) | 二苯并吡喃 | C22H32O2 | 41.0 ± 3.8 | 20622-30-4 | |||
JWH-130 (Δ8-THCB) | 二苯并吡喃 | C20H28O2 | 65.0 ± 13 | 51768-59-3 | |||
JWH-133[7] | 二苯并吡喃 | C22H32O | 677 ± 132 | 3.4 ± 1.0 | CB2 (200x) | 259869-55-1 | |
JWH-138[11] | 二苯并吡喃 | C24H36O2 | 8.5 ± 1.4 | 431041-39-3 | |||
JWH-139[12] | 二苯并吡喃 | C21H30O | 2290 ± 505 | 14 ± 10 | CB2 (164x) | 259869-54-0 | |
JWH-142[7] | 二苯并吡喃 | C26H40O2 | 529 ± 49 | 35 ± 14 | CB2 (15x) | 174627-56-6 | |
JWH-143[7] | 二苯并吡喃 | C26H40O2 | 924 ± 104 | 65 ± 8 | CB2 (14x) | 174627-50-0 | |
JWH-145[13] | 萘甲酰基吡咯 | C26H25NO | 14 ± 2 | 6.4 ± 0.4 | CB2 (2.2x) | 914458-19-8 | |
JWH-146[13] | 萘甲酰基吡咯 | C28H29NO | 21 ± 2 | 62 ± 5 | CB2 (3.0x) | 914458-21-2 | |
JWH-147[13] | 萘甲酰基吡咯 | C27H27NO | 11 ± 1 | 7.1 ± 0.2 | CB2 (1.5x) | 914458-20-1 | |
JWH-148[5] | 萘甲酰基吲哚 | C24H23NO | 123 ± 8 | 14.0 ± 1.0 | CB2 (8x) | 824955-99-9 | |
JWH-149[5] | 萘甲酰基吲哚 | C26H27NO | 5.0 ± 2.1 | 0.73 ± 0.03 | CB2 (6.8x) | 548461-82-1 | |
JWH-150[13] | 萘甲酰基吡咯 | C25H23NO | 60 ± 1 | 15 ± 2 | CB2 (4x) | 914458-18-7 | |
JWH-151[5] | 萘甲酰基吲哚 | C24H23NO2 | >10000 | 30 ± 1.1 | CB2 (>333x) | 824961-23-1 | |
JWH-153[5] | 萘甲酰基吲哚 | C26H27NO2 | 250 ± 24 | 11 ± 0.5 | CB2 (23x) | 824961-58-2 | |
JWH-156[13] | 萘甲酰基吡咯 | C24H21NO | 404 ± 18 | 104 ± 18 | CB2 (4x) | 914458-17-6 | |
JWH-159[5] | 萘甲酰基吲哚 | C26H27NO2 | 45 ± 1 | 10.4 ± 1.4 | CB2 (4.3x) | 824961-62-8 | |
JWH-160[5] | 萘甲酰基吲哚 | C24H23NO2 | 1568 ± 201 | 441 ± 110 | CB2 (3.6x) | 824961-60-6 | |
JWH-161 | 二苯并吡喃 | C27H33NO2 | 19.0 | 1349418-89-8 | |||
JWH-163[5] | 萘甲酰基吲哚 | C23H21NO2 | 2358 ± 215 | 138 ± 12 | CB2 (17x) | 824961-06-0 | |
JWH-164[5] | 萘甲酰基吲哚 | C25H25NO2 | 6.6 ± 0.7 | 6.9 ± 0.2 | — | 824961-61-7 | |
JWH-165[5] | 萘甲酰基吲哚 | C23H21NO2 | 204 ± 26 | 71 ± 8 | CB2 (2.9x) | 824961-59-3 | |
JWH-166[5] | 萘甲酰基吲哚 | C25H25NO2 | 44 ± 10 | 1.9 ± 0.08 | CB2 (23x) | 824961-41-3 | |
JWH-167 | 苯乙酰吲哚 | C21H23NO | 90 ± 17 | 159 ± 14 | CB1 (1.77x) | 864445-37-4 | |
JWH-171 | 碳氢 | C25H24 | 51 | 619294-62-1 | |||
JWH-175[10] | 萘甲基吲哚 | C24H25N | 22 ± 2 | 619294-35-8 | |||
JWH-176[10] | 碳氢 | C25H24 | 26 ± 4 | 619294-62-1 | |||
JWH-180[5] | 萘甲酰基吲哚 | C25H25NO | 26 ± 2 | 9.6 ± 2.0 | CB2 (2.7x) | 824959-87-7 | |
JWH-181[5] | 萘甲酰基吲哚 | C28H31NO | 1.3 ± 0.1 | 0.62 ± 0.04 | CB2 (2.1x) | 824960-03-4 | |
JWH-182[5] | 萘甲酰基吲哚 | C27H29NO | 0.65 ± 0.03 | 1.1 ± 0.1 | CB1 (1.7x) | 824960-02-3 | |
JWH-184[10] | 萘甲基吲哚 | C25H27N | 23 ± 6 | 619294-37-0 | |||
JWH-185[10] | 萘甲基吲哚 | C25H27NO | 17 ± 3 | 619294-39-2 | |||
JWH-186[14] | 二苯并吡喃 | C21H30O2 | 187 ± 23 | 5.6 ± 1.7 | CB2 (33x) | 824430-33-3 | |
JWH-187[14] | 二苯并吡喃 | C22H32O2 | 84 ± 16 | 3.4 ± 0.5 | CB2 (25x) | 824430-34-4 | |
JWH-188[14] | 二苯并吡喃 | C20H28O2 | 270 ± 58 | 18 ± 2 | CB2 (15x) | 824430-32-2 | |
JWH-189[5] | 萘甲酰基吲哚 | C26H27NO | 52 ± 2 | 12 ± 0.8 | CB2 (4.3x) | 824960-01-2 | |
JWH-190[14] | 二苯并吡喃 | C23H34O2 | 8.8 ± 1.4 | 1.6 ± 0.03 | CB2 (5.5x) | 824430-35-5 | |
JWH-191[14] | 二苯并吡喃 | C24H36O2 | 1.8 ± 0.3 | 0.52 ± 0.03 | CB2 (3.5x) | 824430-36-6 | |
JWH-192[10] | 萘甲基吲哚 | C26H28N2O | 41 ± 13 | 619294-55-2 | |||
JWH-193[10] | 萘甲酰基吲哚 | C26H26N2O2 | 6 ± 1 | 133438-58-1 | |||
JWH-194[10] | 萘甲基吲哚 | C26H29N | 127 ± 19 | 619294-43-8 | |||
JWH-195[10] | 萘甲基吲哚 | C25H26N2O | 113 ± 28 | 619294-53-0 | |||
JWH-196[10] | 萘甲基吲哚 | C25H27N | 151 ± 18 | 619294-41-6 | |||
JWH-197[10] | 萘甲基吲哚 | C26H29NO | 323 ± 98 | {619294-45-0 | |||
JWH-198[10] | 萘甲酰基吲哚 | C26H26N2O3 | 10 ± 2 | 166599-76-4 | |||
JWH-199[10] | 萘甲基吲哚 | C26H28N2O2 | 20 ± 2 | 619294-57-4 | |||
JWH-200[10] | 萘甲酰基吲哚 | C25H24N2O2 | 42 ± 5 | 103610-04-4 |
201—300
编辑名称 | 类别 | 分子式 | Ki/nM (CB1) | Ki/nM (CB2) | 选择性 | 结构 | CAS编号 |
---|---|---|---|---|---|---|---|
JWH-201[15] | 苯乙酰吲哚 | C22H25NO2 | 1064 ± 21 | 444 ± 14 | CB2 (2.4x) | 864445-47-6 | |
JWH-202[15] | 苯乙酰吲哚 | C23H27NO2 | 1678 ± 63 | 645 ± 6 | CB2 (2.6x) | 864445-48-7 | |
JWH-203[15] | 苯乙酰吲哚 | C21H22ClNO | 8.0 ± 0.9 | 7.0 ± 1.3 | — | 864445-54-5 | |
JWH-204[15] | 苯乙酰吲哚 | C22H24ClNO | 13 ± 1 | 25 ± 1 | CB1 (1.9x) | 864445-55-6 | |
JWH-205[15] | 苯乙酰吲哚 | C22H25NO | 124 ± 23 | 180 ± 9 | CB1 (1.45x) | 864445-38-5 | |
JWH-206[15] | 苯乙酰吲哚 | C21H22ClNO | 389 ± 25 | 498 ± 37 | CB1 (1.28x) | 864445-58-9 | |
JWH-207[15] | 苯乙酰吲哚 | C22H24ClNO | 1598 ± 134 | 3723 ± 10 | CB1 (2.33x) | 864445-59-0 | |
JWH-208[15] | 苯乙酰吲哚 | C22H25NO | 179 ± 7 | 570 ± 127 | CB1 (3.18x) | 864445-41-0 | |
JWH-209[15] | 苯乙酰吲哚 | C23H27NO | 746 ± 49 | 1353 ± 270 | CB1 (1.81x) | 864445-42-1 | |
JWH-210[5] | 萘甲酰基吲哚 | C26H27NO | 0.46 ± 0.03 | 0.69 ± 0.01 | CB1 (1.5x) | 824959-81-1 | |
JWH-211[5] | 萘甲酰基吲哚 | C25H25NO | 70 ± 0.8 | 12 ± 0.8 | CB2 (5.8x) | 824959-72-0 | |
JWH-212[5] | 萘甲酰基吲哚 | C24H23NO | 33 ± 0.9 | 10 ± 1.2 | CB2 (3.3x) | 824959-71-9 | |
JWH-213[5] | 萘甲酰基吲哚 | C27H29NO | 1.5 ± 0.2 | 0.42 ± 0.05 | CB2 (3.6x) | 824959-83-3 | |
JWH-215[14] | 二苯并吡喃 | C22H32O3 | 1008 ± 117 | 85 ± 21 | CB2 (12x) | 525588-32-3 | |
JWH-216[14] | 二苯并吡喃 | C21H30O3 | 1856 ± 148 | 333 ± 104 | CB2 (5.6x) | 525588-30-1 | |
JWH-217[14] | 二苯并吡喃 | C22H32O2 | >10000 | 1404 ± 66 | CB2 (>7x) | 525588-02-7 | |
JWH-220 | 碳氢 | C26H26 | 19 | ||||
JWH-224[14] | 二苯并吡喃 | C23H34O3 | 347 ± 34 | 28 ± 1 | CB2 (12.3x) | 525588-34-5 | |
JWH-225[14] | 二苯并吡喃 | C23H34O2 | >10000 | 325 ± 70 | CB2 (>31x) | 525588-03-8 | |
JWH-226[14] | 二苯并吡喃 | C24H36O2 | 4001 ± 282 | 43 ± 3 | CB2 (93x) | 525588-04-9 | |
JWH-227[14] | 二苯并吡喃 | C24H36O3 | 40 ± 6 | 4.4 ± 0.3 | CB2 (9x) | 525588-36-7 | |
JWH-229[16] | 二苯并吡喃 | C25H38O2 | 3134 ± 110 | 18 ± 2 | CB2 (174x) | 832111-99-6 | |
JWH-230[14] | 二苯并吡喃 | C25H38O3 | 15 ± 3 | 1.4 ± 0.12 | CB2 (10.7x) | 525588-38-9 | |
JWH-233[14] | 二苯并吡喃 | C26H40O3 | 14 ± 3 | 1.0 ± 0.3 | CB2 (14x) | 137945-55-2 ((6aR,10aR)) 2309315-66-8 ((6aS,10aS)) | |
JWH-234[5] | 萘甲酰基吲哚 | C26H27NO | 8.4 ± 1.8 | 3.8 ± 0.6 | CB2 (2.2x) | 824960-64-7 | |
JWH-235[5] | 萘甲酰基吲哚 | C24H23NO | 338 ± 34 | 123 ± 34 | CB2 (2.7x) | 824960-57-8 | |
JWH-236[5] | 萘甲酰基吲哚 | C25H25NO | 1351 ± 204 | 240 ± 63 | CB2 (5.6x) | 824960-63-6 | |
JWH-237[15] | 苯乙酰吲哚 | C21H22ClNO | 38 ± 10 | 106 ± 2 | CB1 (2.8x) | 864445-56-7 | |
JWH-239[5] | 萘甲酰基吲哚 | C26H27NO | 342 ± 20 | 52 ± 6 | CB2 (6.6x) | 824960-04-5 | |
JWH-240[5] | 萘甲酰基吲哚 | C28H31NO | 14 ± 1 | 7.2 ± 1.3 | CB2 (1.9x) | 824960-06-7 | |
JWH-241[5] | 萘甲酰基吲哚 | C27H29NO | 147 ± 20 | 49 ± 7 | CB2 (3.0x) | 824960-05-6 | |
JWH-242[5] | 萘甲酰基吲哚 | C29H33NO | 42 ± 9 | 6.5 ± 0.3 | CB2 (6.5x) | 824960-07-8 | |
JWH-243[13] | 萘甲酰基吡咯 | C27H27NO2 | 285 ± 40 | 41 ± 3 | CB2 (6.95x) | 914458-38-1 | |
JWH-244[13] | 萘甲酰基吡咯 | C27H27NO | 130 ± 6 | 18 ± 1 | CB2 (7.22x) | 914458-35-8 | |
JWH-245[13] | 萘甲酰基吡咯 | C26H24ClNO | 276 ± 4 | 25 ± 2 | CB2 (11x) | 914458-40-5 | |
JWH-246[13] | 萘甲酰基吡咯 | C26H24ClNO | 70 ± 4 | 16 ± 1 | CB2 (4.38x) | 914458-32-5 | |
JWH-247[14] | 二苯并吡喃 | C25H38O2 | 427 ± 31 | 99 ± 4 | CB2 (4.3x) | 873428-67-2 | |
JWH-248[15] | 苯乙酰吲哚 | C21H22BrNO | 1028 ± 39 | 657 ± 19 | CB2 (1.56x) | 864445-62-5 | |
JWH-249[15] | 苯乙酰吲哚 | C21H22BrNO | 8.4 ± 1.8 | 20 ± 2 | CB1 (2.38x) | 864445-60-3 | |
JWH-250[15] | 苯乙酰吲哚 | C22H25NO2 | 11 ± 2 | 33 ± 2 | CB1 (3x) | 864445-43-2 | |
JWH-251[15] | 苯乙酰吲哚 | C22H25NO | 29 ± 3 | 146 ± 36 | CB2 (5x) | 864445-39-6 | |
JWH-252[15] | 苯乙酰吲哚 | C23H27NO | 23 ± 3 | 19 ± 1 | CB2 (1.2x) | 864445-40-9 | |
JWH-253[15] | 苯乙酰吲哚 | C23H27NO2 | 62 ± 10 | 84 ± 12 | CB1 (1.35x) | 864445-46-5 | |
JWH-254[14] | 二苯并吡喃 | C23H34O2 | 4724 ± 509 | 319 ± 16 | CB2 (14.8x) | 873428-46-7 | |
JWH-256[14] | 二苯并吡喃 | C24H36O2 | 4300 ± 888 | 97 ± 18 | CB2 (44x) | 873428-65-0 | |
JWH-258[5] | 萘甲酰基吲哚 | C26H27NO2 | 4.6 ± 0.6 | 10.5 ± 1.3 | CB1 (2.3x) | 824960-97-6 | |
JWH-259[5] | 萘甲酰基吲哚 | C24H23NO2 | 220 ± 29 | 74 ± 7 | CB2 (3.0x) | 824960-95-4 | |
JWH-260[5] | 萘甲酰基吲哚 | C27H29NO2 | 29 ± 0.4 | 25 ± 1.9 | CB2 (1.2x) | 824960-98-7 | |
JWH-261[5] | 萘甲酰基吲哚 | C25H25NO2 | 767 ± 105 | 221 ± 14 | CB2 (3.5x) | 824960-96-5 | |
JWH-262[5] | 萘甲酰基吲哚 | C27H29NO | 28 ± 3 | 5.6 ± 0.7 | CB2 (5.0x) | 824960-71-6 | |
JWH-265[5] | 萘甲酰基吲哚 | C23H21NO2 | 3788 ± 323 | 80 ± 13 | CB2 (47x) | 824960-73-8 | |
JWH-266[5] | 萘甲酰基吲哚 | C24H23NO2 | >10000 | 455 ± 55 | CB2 (>22x) | 824960-74-9 | |
JWH-267[5] | 萘甲酰基吲哚 | C25H25NO2 | 381 ± 16 | 7.2 ± 0.14 | CB2 (53x) | 824960-76-1 | |
JWH-268[5] | 萘甲酰基吲哚 | C26H27NO2 | 1379 ± 193 | 40 ± 0.6 | CB2 (34x) | 824960-77-2 | |
JWH-277[14] | 二苯并吡喃 | C22H34O3 | 3905 ± 91 | 589 ± 65 | CB2 (6.6x) | 883111-60-2 | |
JWH-278[14] | 二苯并吡喃 | C23H36O3 | 906 ± 80 | 69 ± 6 | CB2 (13x) | 883111-61-3 | |
JWH-292[13] | 萘甲酰基吡咯 | C27H27NO2 | 29 ± 1 | 20 ± 1 | CB2 (1.45x) | 914458-25-6 | |
JWH-293[13] | 萘甲酰基吡咯 | C26H24N2O3 | 100 ± 5 | 41 ± 4 | CB2 (2.44x) | 914458-34-7 | |
JWH-298[14] | 二苯并吡喃 | C22H34O3 | 812 ± 67 | 198 ± 23 | CB2 (4.1x) | 883111-53-3 | |
JWH-299[14] | 二苯并吡喃 | C23H36O3 | 415 ± 50 | 30 ± 2 | CB2 (13.8x) | 883111-54-4 | |
JWH-300[12] | 二苯并吡喃 | C22H34O2 | 118 ± 16 | 5.3 ± 0.1 | CB2 (22x) | 883111-58-8 |
301—400
编辑名称 | 类别 | 分子式 | Ki/nM (CB1) | Ki/nM (CB2) | 选择性 | 结构 | CAS编号 |
---|---|---|---|---|---|---|---|
JWH-301[14] | 二苯并吡喃 | C22H34O2 | 295 ± 64 | 48 ± 4 | CB2 (6.1x) | 883111-65-7 | |
JWH-302[15] | 苯乙酰吲哚 | C22H25NO2 | 17 ± 2 | 89 ± 15 | CB1 (5.26x) | 864445-45-4 | |
JWH-303[15] | 苯乙酰吲哚 | C22H24ClNO | 117 ± 10 | 138 ± 12 | CB1 (1.18x) | 864445-57-8 | |
JWH-304[15] | 苯乙酰吲哚 | C22H24BrNO | 3363 ± 332 | 2679 ± 688 | CB2 (1.26x) | 864445-63-6 | |
JWH-305[15] | 苯乙酰吲哚 | C22H24BrNO | 15 ± 1.8 | 29 ± 5 | CB1 (1.93x) | 864445-61-4 | |
JWH-306[15] | 苯乙酰吲哚 | C23H27NO2 | 25 ± 1 | 82 ± 11 | CB1 (3.28x) | 864445-44-3 | |
JWH-307[13] | 萘甲酰基吡咯 | C26H24FNO | 7.7 ± 1.8 | 3.3 ± 0.2 | CB2 (2.33x) | 914458-26-7 | |
JWH-308[13] | 萘甲酰基吡咯 | C26H24FNO | 41 ± 1 | 33 ± 2 | CB2 (1.24x) | 914458-42-7 | |
JWH-309[13] | 萘甲酰基吡咯 | C30H27NO | 41 ± 3 | 49 ± 7 | CB1 (1.20x) | 914458-42-7 | |
JWH-310[14] | 二苯并吡喃 | C21H32O2 | 1059 ± 51 | 36 ± 3 | CB2 (29x) | 883111-57-7 | |
JWH-311[15] | 苯乙酰吲哚 | C21H22FNO | 23 ± 2 | 39 ± 3 | CB1 (1.70x) | 864445-49-8 | |
JWH-312[15] | 苯乙酰吲哚 | C21H22FNO | 72 ± 7 | 91 ± 20 | CB1 (1.26x) | 864445-50-1 | |
JWH-313[15] | 苯乙酰吲哚 | C21H22FNO | 422 ± 19 | 365 ± 92 | CB2 (1.16x) | 864445-52-3 | |
JWH-314[15] | 苯乙酰吲哚 | C22H24FNO | 39 ± 2 | 76 ± 4 | CB1 (1.95x) | 864382-14-9 | |
JWH-315[15] | 苯乙酰吲哚 | C22H24FNO | 430 ± 24 | 182 ± 23 | CB2 (3.36x) | 864445-51-2 | |
JWH-316[15] | 苯乙酰吲哚 | C22H24FNO | 2862 ± 670 | 781 ± 105 | CB2 (3.66x) | 864445-53-4 | |
JWH-336[12] | 二苯并吡喃 | C21H32O2 | 4589 ± 367 | 153 ± 15 | CB2 (30x) | 883111-64-6 | |
JWH-338[14] | 二苯并吡喃 | C20H28O | >10000 | 111 ± 16 | CB2 (>90x) | 873428-27-4 | |
JWH-339[14] | 二苯并吡喃 | C21H30O2 | >10000 | 2317 ± 93 | CB2 (>4.3x) | 873428-28-5 | |
JWH-340[14] | 二苯并吡喃 | C25H40O3 | 135 ± 6 | 30 ± 1 | CB2 (4.5x) | 259869-53-9 | |
JWH-341[14] | 二苯并吡喃 | C25H40O3 | 100 ± 8 | 10 ± 0.1 | CB2 (10x) | 259869-52-8 | |
JWH-346[13] | 萘甲酰基吡咯 | C27H27NO | 67 ± 6 | 39 ± 2 | CB2 (1.72x) | 914458-29-0 | |
JWH-347[13] | 萘甲酰基吡咯 | C30H27NO | 333 ± 17 | 169 ± 17 | CB2 (1.97x) | 914458-43-8 | |
JWH-348[13] | 萘甲酰基吡咯 | C27H24F3NO | 218 ± 19 | 53 ± 1 | CB2 (4.11x) | 914458-41-6 | |
JWH-349[14] | 二苯并吡喃 | C24H38O3 | 376 ± 1 | 38 ± 4 | CB2 (9.9x) | 883111-67-9 | |
JWH-350[12] | 二苯并吡喃 | C24H38O3 | 395 ± 50 | 12 ± 1 | CB2 (33x) | 883111-59-9 | |
JWH-351[14] | 二苯并吡喃 | C22H32O2 | >10000 | 295 ± 3 | CB2 (>34x) | 873428-30-9 | |
JWH-352[14] | 二苯并吡喃 | C21H30O | >10000 | 47 ± 2 | CB2 (>213x) | 873556-64-0 | |
JWH-353[14] | 二苯并吡喃 | C22H32O | 1493 ± 10 | 31 ± 1 | CB2 (48x) | 873556-72-0 | |
JWH-354[14] | 二苯并吡喃 | C23H34O2 | 1961 ± 21 | 241 ± 14 | CB2 (8.1x) | 873428-58-1 | |
JWH-355[14] | 二苯并吡喃 | C23H34O | 2162 ± 220 | 108 ± 17 | CB2 (20x) | 873428-49-0 | |
JWH-356[14] | 二苯并吡喃 | C24H36O2 | 5837 ± 701 | 108 ± 17 | CB2 (54x) | 873428-61-6 | |
JWH-357[14] | 二苯并吡喃 | C24H36O | 647 ± 78 | 185 ± 4 | CB2 (3.5x) | 873428-50-3 | |
JWH-358[14] | 二苯并吡喃 | C25H38O2 | 1243 ± 266 | 52 ± 3 | CB2 (24x) | 873428-63-8 | |
JWH-359 | 二苯并吡喃 | C24H36O2 | 2918 ± 450 | 13.0 ± 0.2 | CB2 (220x) | ||
JWH-360[14] | 二苯并吡喃 | C21H30O | 2449 ± 606 | 160 ± 8 | CB2 (15x) | 873428-44-5 | |
JWH-361[14] | 二苯并吡喃 | C23H36O2 | 63 ± 3 | 2.7 ± 0.1 | CB2 (23x) | 883111-59-9 | |
JWH-362[14] | 二苯并吡喃 | C23H36O2 | 127 ± 8 | 34 ± 5 | CB2 (3.7x) | 883111-67-9 | |
JWH-363[13] | 萘甲酰基吡咯 | C27H24F3NO | 245 ± 5 | 71 ± 1 | CB2 (3.45x) | 914458-33-6 | |
JWH-364[13] | 萘甲酰基吡咯 | C28H29NO | 34 ± 3 | 29 ± 1 | CB2 (1.17x) | 914458-36-9 | |
JWH-365[13] | 萘甲酰基吡咯 | C28H29NO | 17 ± 1 | 3.4 ± 0.2 | CB2 (5.0x) | 914458-23-4 | |
JWH-366[13] | 萘甲酰基吡咯 | C25H24N2O | 191 ± 12 | 24 ± 1 | CB2 (7.96x) | 914458-44-9 | |
JWH-367[13] | 萘甲酰基吡咯 | C27H27NO2 | 53 ± 2 | 23 ± 1 | CB2 (2.30x) | 914458-30-3 | |
JWH-368[13] | 萘甲酰基吡咯 | C26H24FNO2 | 16 ± 1 | 9.1 ± 0.7 | CB2 (1.76x) | 914458-31-4 | |
JWH-369[13] | 萘甲酰基吡咯 | C26H24ClNO2 | 7.9 ± 0.4 | 5.2 ± 0.3 | CB2 (1.52x) | 914458-27-8 | |
JWH-370[13] | 萘甲酰基吡咯 | C27H27NO | 5.6 ± 0.4 | 4.0 ± 0.5 | CB2 (1.40x) | 914458-22-3 | |
JWH-371[13] | 萘甲酰基吡咯 | C30H33NO | 42 ± 1 | 64 ± 2 | CB1 (1.52x) | 914458-37-0 | |
JWH-372[13] | 萘甲酰基吡咯 | C27H24F3NO | 77 ± 2 | 8.2 ± 0.2 | CB1 (9.39x) | 914458-28-9 | |
JWH-373[13] | 萘甲酰基吡咯 | C30H33NO | 60 ± 3 | 69 ± 2 | CB1 (1.15x) | 914458-37-0 | |
JWH-387[17] | 萘甲酰基吲哚 | C24H22BrNO | 1.2 ± 0.1 | 1.1 ± 0.1 | — | 1366067-59-5 | |
JWH-398[18] | 萘甲酰基吲哚 | C24H22ClNO | 2.3 ± 0.1 | 2.8 ± 0.2 | CB1 (1.22x) | 1292765-18-4 |
401—
编辑名称 | 类别 | 分子式 | Ki/nM (CB1) | Ki/nM (CB2) | 选择性 | 结构 | CAS编号 |
---|---|---|---|---|---|---|---|
JWH-416[17] | 萘甲酰基吲哚 | 73 ± 10 | 3.3 ± 0.1 | CB2 (22x) | 1366068-19-0 | ||
JWH-417[17] | 萘甲酰基吲哚 | 522 ± 58 | 13 ± 0.2 | CB2 (40x) | 1366068-23-6 | ||
JWH-422[17] | 萘甲酰基吲哚 | 501 ± 48 | 20 ± 0.4 | CB2 (25x) | 1366067-69-7 | ||
JWH-423[17] | 萘甲酰基吲哚 | 140 ± 10 | 6.6 ± 0.2 | CB2 (21x) | 1366067-66-4 | ||
JWH-424[17] | 萘甲酰基吲哚 | C24H22BrNO | 21 ± 3.4 | 5.4 ± 0.2 | CB2 (3.9x) | 1366068-04-3 | |
JWH-425[17] | 萘甲酰基吲哚 | C25H24BrNO | 54 ± 11 | 10 ± 0.4 | CB2 (5.4x) | 1366068-07-6 |
参见
编辑注释
编辑参考资料
编辑- ^ Manera C, Tuccinardi T, Martinelli A. Indoles and related compounds as cannabinoid ligands. Mini Rev Med Chem. 2008, 8 (4): 370–87. PMID 18473928. doi:10.2174/138955708783955935.
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- ^ Wiley JL, Marusich JA, Thomas BF. Combination Chemistry: Structure-Activity Relationships of Novel Psychoactive Cannabinoids. Curr Top Behav Neurosci. Current Topics in Behavioral Neurosciences. 2017, 32: 231–248. ISBN 978-3-319-52442-9. PMID 27753007. doi:10.1007/7854_2016_17 .
- ^ Banister SD, Connor M. The Chemistry and Pharmacology of Synthetic Cannabinoid Receptor Agonists as New Psychoactive Substances: Origins. Handb Exp Pharmacol. Handbook of Experimental Pharmacology. 2018, 252: 165–190. ISBN 978-3-030-10560-0. PMID 29980914. doi:10.1007/164_2018_143.
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- ^ 6.00 6.01 6.02 6.03 6.04 6.05 6.06 6.07 6.08 6.09 6.10 6.11 6.12 6.13 6.14 6.15 6.16 6.17 6.18 6.19 6.20 6.21 6.22 6.23 Aung MM, Griffin G, Huffman JW, Wu M, Keel C, Yang B, Showalter VM, Abood ME, Martin BR. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB(1) and CB(2) receptor binding. Drug and Alcohol Dependence. August 2000, 60 (2): 133–40. PMID 10940540. doi:10.1016/S0376-8716(99)00152-0.
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- ^ Bow EW, Rimoldi JM. The Structure-Function Relationships of Classical Cannabinoids: CB1/CB2 Modulation. Perspect Medicin Chem. 2016 Jun 28;8:17-39. doi:10.4137/PMC.S32171 PMID 27398024
- ^ 10.00 10.01 10.02 10.03 10.04 10.05 10.06 10.07 10.08 10.09 10.10 10.11 10.12 10.13 10.14 Huffman JW, Mabon R, Wu MJ, Lu J, Hart R, Hurst DP, Reggio PH, Wiley JL, Martin BR. 3-Indolyl-1-naphthylmethanes: new cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB(1) cannabinoid receptor. Bioorganic & Medicinal Chemistry. February 2003, 11 (4): 539–49. PMID 12538019. S2CID 29107765. doi:10.1016/S0968-0896(02)00451-0.
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- ^ 12.0 12.1 12.2 12.3 Howlett AC, Barth F, Bonner TI, Cabral G, Casellas P, Devane WA, Felder CC, Herkenham M, Mackie K, Martin BR, Mechoulam R, Pertwee RG. International Union of Pharmacology. XXVII. Classification of cannabinoid receptors. Pharmacological Reviews. June 2002, 54 (2): 161–202. PMID 12037135. S2CID 8259002. doi:10.1124/pr.54.2.161.
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- ^ 17.0 17.1 17.2 17.3 17.4 17.5 17.6 Wiley JL, Smith VJ, Chen J, Martin BR, Huffman JW. Synthesis and pharmacology of 1-alkyl-3-(1-naphthoyl)indoles: Steric and electronic effects of 4- and 8-halogenated naphthoyl substituents. Bioorganic & Medicinal Chemistry. 2012, 20 (6): 2067–2081. PMC 3298571 . PMID 22341572. doi:10.1016/j.bmc.2012.01.038.
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