美西林
青霉素
美西林（INN：Mecillinam；USAN：Amdinocillin）是一种广谱半合成青霉素[2]，对革兰氏阴性菌作用强，也可用来治疗伤寒和副伤寒[3][4]。其口服利用率很差，匹美西林则是针对此缺陷开发出来的。[5]
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| 临床资料 | |
|---|---|
| 商品名 | Coactin, Leo, Selexid, Selexidin |
| AHFS/Drugs.com | 国际药品名称 |
| 怀孕分级 |
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| 给药途径 | 静脉注射、肌肉注射 |
| ATC码 | |
| 法律规范状态 | |
| 法律规范 |
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| 药物动力学数据 | |
| 生物利用度 | 可忽略 |
| 血浆蛋白结合率 | 5-10% |
| 药物代谢 | 肝脏 |
| 生物半衰期 | 1-3小时 |
| 排泄途径 | 肾、胆 |
| 识别信息 | |
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| CAS号 | 32887-01-7  |
| PubChem CID | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.046.601 |
| 化学信息 | |
| 化学式 | C15H23N3O3S |
| 摩尔质量 | 325.426 g/mol |
| 3D模型（JSmol） | |
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这种药物是荷兰制药公司“Leo Pharmaceutical Products”（今利奥制药）研发出来的，最初代号为FL 1060，1972年面世。[6][7]
参考文献
编辑- ^ Nicolle LE. Pivmecillinam in the treatment of urinary tract infections. J Antimicrob Chemother. August 2000, 46 (Suppl A): 35–39. PMID 10969050. doi:10.1093/jac/46.suppl_1.35.
- ^ Neu HC. Amdinocillin: a novel penicillin. Antibacterial activity, pharmacology and clinical use. Pharmacotherapy. 1985, 5 (1): 1–10. PMID 3885172. doi:10.1002/j.1875-9114.1985.tb04448.x.
- ^ Clarke PD, Geddes AM, McGhie D, Wall JC. Mecillinam: a new antibiotic for enteric fever. Br Med J. July 1976, 2 (6026): 14–5. PMC 1687648
. PMID 820402. doi:10.1136/bmj.2.6026.14.
- ^ Geddes AM, Clarke PD. The treatment of enteric fever with mecillinam. J Antimicrob Chemother. July 1977,. 3 Suppl B: 101–2. PMID 408321. doi:10.1093/jac/3.suppl_b.101.
- ^ Pham P, Bartlett JG. Amdinocillin (Mecillinam). Point-of-Care Information Technology ABX Guide. Johns Hopkins University. August 28, 2008 [2019-03-08]. （原始内容存档于2009-02-04）. Retrieved on August 31, 2008. Freely available with registration.
- ^ Lund F, Tybring L. 6β-amidinopenicillanic acids—a new group of antibiotics. Nature New Biology. April 1972, 236 (66): 135–7. PMID 4402006. doi:10.1038/236135c0.
- ^ Tybring L, Melchior NH. Mecillinam (FL 1060), a 6β-Amidinopenicillanic Acid Derivative: Bactericidal Action and Synergy In Vitro. Antimicrob Agents Chemother. September 1975, 8 (3): 271–6 [2019-03-08]. PMC 429305 . PMID 170856. doi:10.1128/aac.8.3.271. （原始内容存档于2019-12-14）.
