α-胎儿蛋白

α-胎儿蛋白（英语：Alpha-Fetoprotein，缩写AFP；又译甲种胎儿球蛋白或甲胎蛋白）是一种α-1球蛋白，由胎儿肠胃道、卵黄囊及肝脏分泌，但可经由肾脏排入尿液、羊水，并通过胎盘进入母体血流中。在正常妊娠时，胎儿血清中之胎儿蛋白浓度于12至14周间达到最高，而母体血清中之浓度则于28至32周间达到最高。如果羊水或母体血清中的α-胎儿蛋白超出正常范围，需考虑胎儿发育异常，例如：神经管缺损、先天性肾病变、肠道闭锁、死胎、胎儿窘迫等。也就是说，α-胎儿蛋白虽是一项非特异指标，但对于产前评估胎儿健康状态甚具临床价值，也是帮助检查胎儿异常的一项筛检工具。

Α-胎儿蛋白
已知的结构 PDB 直系同源搜索: PDBe RCSB PDBID列表 3MRK
识别号
别名	AFP；, AFPD, FETA, HPalpha fetoprotein
外部ID	OMIM：104150 MGI：87951 HomoloGene：36278 GeneCards：AFP
基因位置（人类） 染色体 4号染色体 基因座 4q13.3 起始 73,431,138 bp 终止 73,456,174 bp
基因位置（小鼠） 染色体 小鼠5号染色体 基因座 5 E1|5 44.77 cM 起始 90,638,596 bp 终止 90,656,766 bp
RNA表达模式
查阅更多表达数据
基因本体 分子功能 • 金属离子结合 • 血浆蛋白结合 细胞组分 • 细胞外区域 • 细胞外空间 • 细胞质 • endoplasmic reticulum lumen 生物学过程 • ovulation from ovarian follicle • SMAD protein signal transduction • 有性生殖 • progesterone metabolic process • 翻译后修饰 Sources:Amigo / QuickGO
直系同源
物种	人类	小鼠
Entrez	174	11576
Ensembl	ENSG00000081051	ENSMUSG00000054932
UniProt	P02771	P02772
mRNA​序列	NM_001134 ​NM_001354717	NM_007423
蛋白序列	NP_001125 ​NP_001341646	NP_031449
基因位置​（UCSC）	Chr 4: 73.43 – 73.46 Mb	Chr 5: 90.64 – 90.66 Mb
PubMed​查找
维基数据
查看/编辑人类 查看/编辑小鼠

许多肝病皆可能伴随α-胎儿蛋白之升高，因此可作为临床参考。例如80%-90%的肝细胞癌病人，其血液中的α-胎儿蛋白有升高之现象，故在肝病甚为流行的区域（如台湾），利用α-胎儿蛋白及超声波作为高危险群病人筛检方式，成效良好。再如肝硬化病人当中有些合并有α-胎儿蛋白之升高，这可能代表肝细胞再生的持续进行；但若持续上升则须积极追踪，找出可能的恶性变化。此外，急慢性肝炎患者血中的α-胎儿蛋白常随着肝细胞坏死后之再生而升高。其高峰往往在转氨基的高峰之后；其升高程度间接地反映肝细胞坏死后的再生能力，也因此常被利用作为病理变化及病程预后之参考。

延伸阅读

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