去甲肾上腺素转运体

去甲肾上腺素转运体
识别号
别名	SLC6A2；, NAT1, NET, NET1, SLC6A5, solute carrier family 6 member 2, Norepinephrine transporter, norepinephrine transporter gene
外部ID	OMIM：163970 MGI：1270850 HomoloGene：816 GeneCards：SLC6A2
为以下药物的标靶
	阿米替林、阿莫沙平、阿托莫西汀、丁氨苯丙酮、西酞普兰、氯米帕明、地昔帕明、去甲文拉法辛、右旋安非他命、度洛西汀、丙咪嗪、左旋米那普伦、洛非帕明、马普替林、马吲哚、哌甲酯、奈法唑酮、nisoxetine、(RS)-nomifensine、去甲替林、苯乙肼、普罗替林、喹硫平、𫫇泼西汀、西布曲明、他喷他窦、曲米帕明、文拉法辛、zotepine、serdexmethylphenidate chloride、右旋哌甲酯、右旋安非他命、苯丙胺、liafensine、甲基苯丙胺、phentermine hydrochloride、安非拉酮、去甲文拉法辛、马吲哚、伪麻黄碱、methylphenidate hydrochloride、dasotraline、milnacipran、diethylpropion hydrochloride、bretylium tosylate、desipramine hydrochloride、guanadrel sulfate、imipramine hydrochloride、nefazodone hydrochloride、orphenadrine citrate、phenmetrazine hydrochloride、protriptyline hydrochloride、(+)-pseudoephedrine hydrochloride、venlafaxine hydrochloride
基因位置（人类）
染色体	16号染色体
终止	55,707,645 bp
基因位置（小鼠）
染色体	小鼠8号染色体
终止	93,728,295 bp
RNA表达模式
	; ; ; ;
	查阅更多表达数据
基因本体
分子功能	• dopamine:sodium symporter activity; • neurotransmitter:sodium symporter activity; • norepinephrine:sodium symporter activity; • monoamine transmembrane transporter activity; • 血浆蛋白结合; • symporter activity; • 金属离子结合; • beta-tubulin binding; • alpha-tubulin binding; • actin binding;
细胞组分	• integral component of membrane; • 细胞膜; • 膜; • 脂筏模型; • neuron projection; • cell surface; • integral component of plasma membrane; • neuronal cell body membrane; • presynaptic membrane;
生物学过程	• dopamine uptake involved in synaptic transmission; • neurotransmitter transport; • response to pain; • monoamine transport; • 化学性突触传递; • norepinephrine transport; • transmembrane transport; • sodium ion transmembrane transport; • norepinephrine uptake; • neuron cellular homeostasis; • 再摄取;
	Sources:Amigo / QuickGO
直系同源
	6530
	20538
	ENSG00000103546
	ENSMUSG00000055368
	P23975
	O55192
	NM_001043; NM_001172501; NM_001172502; NM_001172504
	NM_009209
	NP_001034; NP_001165972; NP_001165973; NP_001165975
	NP_033235
	维基数据
查看/编辑人类	查看/编辑小鼠

去甲肾上腺素转运体（英语：Norepinephrine_transporter，NET），也被称为溶质载体家族6成员2（英语：solute carrier family 6 member 2，SLC6A2），是由SLC6A2基因编码的蛋白质。^[6]。NET是一种单胺转运体（英语：monoamine transporter），负责依赖Na⁺/Cl⁻的胞外去甲肾上腺素再摄取。NET也可转运多巴胺。对这两种神经递质的再吸收是调控突触间隙（英语：synaptic cleft）传导物浓度的重要机制。

NET以及其他单胺转运体是不少抗抑郁剂以及娱乐性药物的作用对象。过少的NET跟直立不耐症（英语：orthostatic intolerance）相关，过多NET则和ADHD相关。^[7]^[8]

参见

神经递质转运体（英语：Neurotransmitter transporter）
Sodium:neurotransmitter symporter（英语：Sodium:neurotransmitter symporter）
溶质载体家族（英语：Solute carrier family）
去甲肾上腺素
单胺转运体（英语：Monoamine transporter）
直立不耐症（英语：Orthostatic intolerance）
单核苷酸多态性

参考资料

^ 對Solute carrier family 6 member 2起作用的藥物；在維基數據上查看/編輯參考.
^ ^2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000103546 - Ensembl, May 2017
^ ^3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000055368 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Pacholczyk T, Blakely RD, Amara SG. Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter. Nature. Mar 1991, 350 (6316): 350–4. PMID 2008212. doi:10.1038/350350a0.
^ Schroeter S, Apparsundaram S, Wiley RG, Miner LH, Sesack SR, Blakely RD. Immunolocalization of the cocaine- and antidepressant-sensitive l-norepinephrine transporter. The Journal of Comparative Neurology. May 2000, 420 (2): 211–32. PMID 10753308. doi:10.1002/(SICI)1096-9861(20000501)420:2<211::AID-CNE5>3.0.CO;2-3.
^ Tellioglu T, Robertson D. Genetic or acquired deficits in the norepinephrine transporter: current understanding of clinical implications. Expert Reviews in Molecular Medicine. Nov 2001, 2001 (29): 1–10. PMID 14987367. doi:10.1017/S1462399401003878.

外部链接

医学主题词表（MeSH）：Norepinephrine+transporter

[1] 對Solute carrier family 6 member 2起作用的藥物；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-2] 2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000103546 - Ensembl, May 2017

[refGRCm38Ensembl-3] 3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000055368 - Ensembl, May 2017

[4] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2008212-6] Pacholczyk T, Blakely RD, Amara SG. Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter. Nature. Mar 1991, 350 (6316): 350–4. PMID 2008212. doi:10.1038/350350a0.

[7] Schroeter S, Apparsundaram S, Wiley RG, Miner LH, Sesack SR, Blakely RD. Immunolocalization of the cocaine- and antidepressant-sensitive l-norepinephrine transporter. The Journal of Comparative Neurology. May 2000, 420 (2): 211–32. PMID 10753308. doi:10.1002/(SICI)1096-9861(20000501)420:2<211::AID-CNE5>3.0.CO;2-3.

[pmid14987367-8] Tellioglu T, Robertson D. Genetic or acquired deficits in the norepinephrine transporter: current understanding of clinical implications. Expert Reviews in Molecular Medicine. Nov 2001, 2001 (29): 1–10. PMID 14987367. doi:10.1017/S1462399401003878.

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