多塞平
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多塞平(英语:Doxepin)是一种含氮有机化合物,化学式C19H21NO,属于三环类抗抑郁药(TCA)。[4][5]
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临床资料 | |
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商品名 | Sinequan, Quitaxon, Adapin, Triadapin, Aponal, others |
其他名称 | NSC-108160 |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682390 |
核准状况 | |
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给药途径 | By mouth, topical, intravenous, intramuscular injection[1] |
药物类别 | 三环类抗抑郁药(TCA) |
ATC码 | |
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法律规范 |
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药物动力学数据 | |
生物利用度 | 13–45% (mean 29%)[2] |
血浆蛋白结合率 | 76% |
药物代谢 | Hepatic (CYP2D6, CYP2C19)[2] |
代谢产物 | Nordoxepin, glucuronide conjugates |
生物半衰期 | Doxepin: 8–24 hours (mean 17 hours) Nordoxepin: 28–31 hours |
排泄途径 | Urine: ~50%[2] Feces: minor[2] |
识别信息 | |
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CAS号 | 1668-19-5( 1229-29-4 (hydrochloride) 3607-18-9 (cidoxepin)) ![]() |
PubChem CID | |
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CompTox Dashboard (EPA) | |
化学信息 | |
化学式 | C19H21NO |
摩尔质量 | 279.38 g·mol−1 |
3D模型(JSmol) | |
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参考文献
编辑- ^ Doxepin Hydrochloride. Martindale: The Complete Drug Reference. London, UK: Pharmaceutical Press. 30 January 2013 [3 December 2013]. (原始内容存档于2021-08-28).
- ^ 2.0 2.1 2.2 2.3 Lemke TL, Williams DA. Antidepressants. Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. 24 January 2012: 604– [2024-01-20]. ISBN 978-1-60913-345-0. (原始内容存档于2023-01-12).
- ^ Anvisa. RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control]. Diário Oficial da União. 2023-03-31 (2023-04-04) [2023-08-16]. (原始内容存档于2023-08-03) (巴西葡萄牙语).
- ^ Doxepin Hydrochloride. Drugs.com. American Society of Health-System Pharmacists. [20 March 2019]. (原始内容存档于2018-12-10).
- ^ Silenor (doxepin) label (PDF). FDA. 17 March 2010 [25 October 2017]. (原始内容存档 (PDF)于2017-02-25). For label updates see FDA index page for NDA 022036 (页面存档备份,存于互联网档案馆)
外部链接
编辑- Doxepin. Drug Information Portal. U.S. National Library of Medicine. [2024-01-20]. (原始内容存档于2022-10-03).
- Doxepin hydrochloride. Drug Information Portal. U.S. National Library of Medicine. [2024-01-20]. (原始内容存档于2022-10-02).