多塞平(英语:Doxepin)是一种含氮有机化合物,化学式C19H21NO,属于三环类抗抑郁药(TCA)。[4][5]

多塞平
临床资料
商品名英语Drug nomenclatureSinequan, Quitaxon, Adapin, Triadapin, Aponal, others
其他名称NSC-108160
AHFS/Drugs.comMonograph
MedlinePlusa682390
核准状况
怀孕分级
  • : C
给药途径By mouth, topical, intravenous, intramuscular injection[1]
药物类别英语Drug class三环类抗抑郁药(TCA)
ATC码
法律规范状态
法律规范
药物动力学数据
生物利用度13–45% (mean 29%)[2]
血浆蛋白结合率76%
药物代谢Hepatic (CYP2D6, CYP2C19)[2]
代谢产物Nordoxepin, glucuronide conjugates
生物半衰期Doxepin: 8–24 hours (mean 17 hours)
Nordoxepin: 28–31 hours
排泄途径Urine: ~50%[2]
Feces: minor[2]
识别信息
  • (E/Z)-3-(dibenzo[b,e]oxepin-11(6H)-ylidene)-N,N-dimethylpropan-1-amine
CAS号1668-19-5
1229-29-4 (hydrochloride)
3607-18-9 (cidoxepin))  checkY
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
PDB配体ID
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
化学信息
化学式C19H21NO
摩尔质量279.38 g·mol−1
3D模型(JSmol英语JSmol
  • CN(C)CC/C=C1C2=C(C=CC=C2)OCC3=C/1C=CC=C3
  • InChI=1S/C19H21NO/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19/h3-6,8-12H,7,13-14H2,1-2H3 checkY
  • Key:ODQWQRRAPPTVAG-UHFFFAOYSA-N checkY

参考文献

编辑
  1. ^ Doxepin Hydrochloride. Martindale: The Complete Drug Reference. London, UK: Pharmaceutical Press. 30 January 2013 [3 December 2013]. (原始内容存档于2021-08-28). 
  2. ^ 2.0 2.1 2.2 2.3 Lemke TL, Williams DA. Antidepressants. Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. 24 January 2012: 604– [2024-01-20]. ISBN 978-1-60913-345-0. (原始内容存档于2023-01-12). 
  3. ^ Anvisa. RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control]. Diário Oficial da União. 2023-03-31 (2023-04-04) [2023-08-16]. (原始内容存档于2023-08-03) (巴西葡萄牙语). 
  4. ^ Doxepin Hydrochloride. Drugs.com. American Society of Health-System Pharmacists. [20 March 2019]. (原始内容存档于2018-12-10). 
  5. ^ Silenor (doxepin) label (PDF). FDA. 17 March 2010 [25 October 2017]. (原始内容存档 (PDF)于2017-02-25).  For label updates see FDA index page for NDA 022036页面存档备份,存于互联网档案馆

外部链接

编辑
  • Doxepin. Drug Information Portal. U.S. National Library of Medicine. [2024-01-20]. (原始内容存档于2022-10-03). 
  • Doxepin hydrochloride. Drug Information Portal. U.S. National Library of Medicine. [2024-01-20]. (原始内容存档于2022-10-02).