葡萄球菌黃素

葡萄球菌黃素
	IUPAC名; [(2S,3R,4S,5S,6R)-3,4, 5-trihydroxy-6-[[(12S)-12-methyltetradecanoyl]oxymethyl]oxan-2-yl](2E,4E,6E,8E,10E,12E,14E,16E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,4,6,8,10,12,14,16,18,22-decaenoate
識別
CAS號	71869-01-7 =
PubChem	24892781
ChemSpider	4947803
SMILES	O=C(O[C@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)CO)\C(=C\C=C\C(C)(C\C=C\C=C(\C=C\C=C(\C=C\C=C(/C)CC\C=C(/C)C)C)C)C(\C=C/CCCCCCCC(C)CC)C=O)C;
ChEBI	71690
性質
化學式	C51H78O8
摩爾質量	819.16 g·mol−1
外觀	金黃色物質
	若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。

葡萄球菌黃素（英語：Staphyloxanthin）是一種由一些金黃色葡萄球菌菌種製造的類胡蘿蔔素。這種色素給了金黃色葡萄球菌它的顏色。

在金黃色葡萄球菌內的作用

葡萄球菌黃素使在瓊脂上生長的金黃色葡萄球菌擁有金黃色

葡萄球菌黃素在金黃色葡萄球菌的感染中扮演了重要的角色。作為一種抗氧化劑，它保護金黃色葡萄球菌免於被白細胞釋放的活性氧殺死。^[2]

一些藥物可以抑制金黃色葡萄球菌製造葡萄球菌黃素並且可以使金黃色葡萄球菌容易被抗生素殺滅。^[3]事實上，由於葡萄球菌黃素和人類膽固醇的合成有相似的步驟，所以降低膽固醇的藥物和治療方法也可以阻止細菌製造葡萄球菌黃素。^[4]

參考文獻

^ Pelz, Alexandra; Wieland, Karsten-Peter; Putzbach, Karsten; Hentschel, Petra; Albert, Klaus; Götz, Friedrich. Structure and Biosynthesis of Staphyloxanthin from Staphylococcus aureus. Journal of Biological Chemistry. 2005, 280 (37): 32493–32498. doi:10.1074/jbc.M505070200.
^ Clauditz, Alexandra; Resch, Alexandra; Wieland, Karsten-Peter; Peschel, Andreas; Götz, Friedrich. Staphyloxanthin Plays a Role in the Fitness of Staphylococcus aureus and Its Ability To Cope with Oxidative Stress. Infection and Immunity. 2006-08, 74 (8): 4950–4953 [2022-01-03]. ISSN 0019-9567. PMC 1539600  . PMID 16861688. doi:10.1128/IAI.00204-06. （原始內容存檔於2022-01-03）（英語）.
^ Liu, George Y.; Essex, Anthony; Buchanan, John T.; Datta, Vivekanand; Hoffman, Hal M.; Bastian, John F.; Fierer, Joshua; Nizet, Victor. Staphylococcus aureus golden pigment impairs neutrophil killing and promotes virulence through its antioxidant activity. Journal of Experimental Medicine. 2005-07-18, 202 (2): 209–215 [2022-01-03]. ISSN 1540-9538. PMC 2213009  . PMID 16009720. doi:10.1084/jem.20050846. （原始內容存檔於2022-03-16）（英語）.
^ Liu, Chia-I; Liu, George Y.; Song, Yongcheng; Yin, Fenglin; Hensler, Mary E.; Jeng, Wen-Yih; Nizet, Victor; Wang, Andrew H.-J.; Oldfield, Eric. A Cholesterol Biosynthesis Inhibitor Blocks Staphylococcus aureus Virulence. Science. 2008-03-07, 319 (5868): 1391–1394 [2022-01-03]. ISSN 0036-8075. PMC 2747771  . PMID 18276850. doi:10.1126/science.1153018. （原始內容存檔於2022-03-02）（英語）.

參見

外部連結

Staphyloxanthin on www.genome.jp （頁面存檔備份，存於互聯網檔案館）（日語）

[1] Pelz, Alexandra; Wieland, Karsten-Peter; Putzbach, Karsten; Hentschel, Petra; Albert, Klaus; Götz, Friedrich. Structure and Biosynthesis of Staphyloxanthin from Staphylococcus aureus. Journal of Biological Chemistry. 2005, 280 (37): 32493–32498. doi:10.1074/jbc.M505070200.

[staphylotoxin-2] Clauditz, Alexandra; Resch, Alexandra; Wieland, Karsten-Peter; Peschel, Andreas; Götz, Friedrich. Staphyloxanthin Plays a Role in the Fitness of Staphylococcus aureus and Its Ability To Cope with Oxidative Stress. Infection and Immunity. 2006-08, 74 (8): 4950–4953 [2022-01-03]. ISSN 0019-9567. PMC 1539600  . PMID 16861688. doi:10.1128/IAI.00204-06. （原始內容存檔於2022-01-03）（英語）.

[JExpMed2005-Liu-3] Liu, George Y.; Essex, Anthony; Buchanan, John T.; Datta, Vivekanand; Hoffman, Hal M.; Bastian, John F.; Fierer, Joshua; Nizet, Victor. Staphylococcus aureus golden pigment impairs neutrophil killing and promotes virulence through its antioxidant activity. Journal of Experimental Medicine. 2005-07-18, 202 (2): 209–215 [2022-01-03]. ISSN 1540-9538. PMC 2213009  . PMID 16009720. doi:10.1084/jem.20050846. （原始內容存檔於2022-03-16）（英語）.

[Science2008-Liu-4] Liu, Chia-I; Liu, George Y.; Song, Yongcheng; Yin, Fenglin; Hensler, Mary E.; Jeng, Wen-Yih; Nizet, Victor; Wang, Andrew H.-J.; Oldfield, Eric. A Cholesterol Biosynthesis Inhibitor Blocks Staphylococcus aureus Virulence. Science. 2008-03-07, 319 (5868): 1391–1394 [2022-01-03]. ISSN 0036-8075. PMC 2747771  . PMID 18276850. doi:10.1126/science.1153018. （原始內容存檔於2022-03-02）（英語）.

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葡萄球菌黃素

IUPAC名 [(2S,3R,4S,5S,6R)-3,4, 5-trihydroxy-6-[[(12S)-12-methyltetradecanoyl]oxymethyl]oxan-2-yl](2E,4E,6E,8E,10E,12E,14E,16E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,4,6,8,10,12,14,16,18,22-decaenoate
識別
CAS號	71869-01-7 ^Y=
PubChem	24892781
ChemSpider	4947803
SMILES	O=C(O[C@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)CO)\C(=C\C=C\C(C)(C\C=C\C=C(\C=C\C=C(\C=C\C=C(/C)CC\C=C(/C)C)C)C)C(\C=C/CCCCCCCC(C)CC)C=O)C
ChEBI	71690
性質
化學式	C₅₁H₇₈O₈
摩爾質量	819.16 g·mol⁻¹
外觀	金黃色物質^[1]
若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。