美法仑
化合物
美法仑(Melphalan,台湾常称为威克瘤注射剂)是一种化学疗法,用于治疗多发性骨髓瘤、卵巢癌、黑色素瘤和淀粉样变[7]。可以口服或静脉注射[7]。
临床资料 | |
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商品名 | Alkeran, Evomela, Phelinun, others |
其他名称 | (2S)-2-amino-3-{4-[bis(2-chloroethyl)amino]phenyl}propanoic acid |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682220 |
核准状况 | |
给药途径 | 口服给药, 静脉注射, 动脉内注射 |
ATC码 | |
法律规范状态 | |
法律规范 | |
药物动力学数据 | |
生物利用度 | 25–89% (口服) |
药物代谢 | 水解成无活性代谢物 |
生物半衰期 | 1.5 ± 0.8 小时 |
排泄途径 | 肾 (IV: 5.8–21.3%) |
识别信息 | |
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CAS号 | 148-82-3 |
PubChem CID | |
IUPHAR/BPS | |
DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
ChEBI | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.005.207 |
化学信息 | |
化学式 | C13H18Cl2N2O2 |
摩尔质量 | 305.20 g·mol−1 |
3D模型(JSmol) | |
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常见副作用包括恶心和骨髓抑制[7]。其他严重副作用包括可能产生严重过敏反应和引发其他癌症[7]。孕期使用可能会对婴儿有害[8]。它属于氮芥类的烷化剂[7]。作用机转是干扰DNA和RNA的产生[7]。
美法仑于 1964 年在美国取得医疗使用许可[7]。名列世界卫生组织基本药物标准清单[9]。已有学名药流通于市[10]。
参考文献
编辑- ^ Prescription medicines: registration of new generic medicines and biosimilar medicines, 2017. Therapeutic Goods Administration (TGA). 21 June 2022 [30 March 2024].
- ^ Alkeran- melphalan tablet, film coated. DailyMed. 18 November 2019 [23 April 2022].
- ^ Evomela- melphalan injection, powder, lyophilized, for solution. DailyMed. 31 December 2021 [23 April 2022].
- ^ Evomela (Captisol-enabled melphalan HCl) for Injection. U.S. Food and Drug Administration (FDA). 30 November 2016 [7 September 2023].
- ^ https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/201848s000lbl.pdf [裸网址]
- ^ Phelinun EPAR. European Medicines Agency (EMA). 15 September 2020 [23 April 2022]. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
- ^ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 Melphalan Monograph for Professionals. Drugs.com. American Society of Health-System Pharmacists. [9 October 2019].
- ^ Melphalan Use During Pregnancy. Drugs.com. [9 October 2019]. (原始内容存档于9 October 2019). 互联网档案馆的存档,存档日期9 October 2019.
- ^ World Health Organization. World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. 2019. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
- ^ British national formulary : BNF 76 76. Pharmaceutical Press. 2018: 873–874. ISBN 9780857113382.