夫西地酸

夫西地酸
临床资料
商品名（英语：Drug nomenclature）	Fucidin, Fucithalmic, Stafine
其他名称	Sodium fusidate
AHFS/Drugs.com	Micromedex详细消费者药物信息
ATC码	D06AX01 (WHO) D09AA02 (dressing) J01XC01 S01AA13;
药物动力学数据
生物利用度	91% oral bioavailability
血浆蛋白结合率	97 to 99%
生物半衰期	Approximately 5 to 6 hours in adults
识别信息
	IUPAC命名法 2-[(1S,2S,5R,6S,7S,10S,11S,13S,14Z,15R,17R)-13-(acetyloxy)-5,17-dihydroxy-2,6,10,11-tetramethyltetracyclo[8.7.0.02,7.011,15]heptadecan-14-ylidene]-6-methylhept-5-enoic acid; ;
CAS号	6990-06-3
PubChem CID	3000226;
DrugBank	DB02703 ;
ChemSpider	2271900 ;
UNII	59XE10C19C;
KEGG	D04281 ;
ChEBI	CHEBI:29013 ;
ChEMBL	ChEMBL374975 ;
PDB配体ID	FUA (PDBe, RCSB PDB);
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID0023086 ;
ECHA InfoCard	100.027.506
化学信息
化学式	C31H48O6
摩尔质量	516.709
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES O=C(O)/C(=C3/[C@@H]2C[C@@H](O)[C@H]1[C@@]4(C)CC[C@@H](O)[C@@H](C)[C@@H]4CC[C@@]1([C@]2(C[C@@H]3OC(=O)C)C)C)CC\C=C(/C)C;
	InChI InChI=1S/C31H48O6/c1-17(2)9-8-10-20(28(35)36)26-22-15-24(34)27-29(5)13-12-23(33)18(3)21(29)11-14-30(27,6)31(22,7)16-25(26)37-19(4)32/h9,18,21-25,27,33-34H,8,10-16H2,1-7H3,(H,35,36)/b26-20-/t18-,21-,22-,23+,24+,25-,27-,29-,30-,31-/m0/s1 ; Key:IECPWNUMDGFDKC-MZJAQBGESA-N ;

夫西地酸（英语：Fusidic acid）是一种甾类抗生素，通常作为软膏和眼药水局部使用，也可作为片剂或注射剂全身使用。在全球范围内，细菌抗生素抗药性的提高引起了人们对其使用的新兴趣^[1]。夫西地酸对大部分抗甲氧西林金黄色葡萄球菌有效，^[2]但为防耐药性产生（转变为耐药菌需要的突变较少），本药应该配合其他抗生素使用^[3]或者以极高浓度单独使用。^[4]

使用单独含本品的药膏、眼药水很容易产生耐药金黄色葡萄球菌，^[5]因此有作者要求停用这类药物，以免“浪费”一种有效的抗生素。^[3]在欧洲，含有夫西地酸的药膏一般也会加入庆大霉素。

夫西地酸软膏对于痤疮成因痤疮丙酸杆菌的效果不如其他抗生素，因此不推荐用于此用途。^[6]

参考文献

^ Falagas ME, Grammatikos AP, Michalopoulos A. Potential of old-generation antibiotics to address current need for new antibiotics. Expert Rev Anti Infect Ther. 2008; 6(5):593-600 doi:10.1586/14787210.6.5.593 PMID 18847400
^ Collignon P, Turnidge J. Fusidic acid in vitro activity. International Journal of Antimicrobial Agents. August 1999, 12 (Supplement 2): S45–S58. PMID 10528786. doi:10.1016/s0924-8579(98)00073-9.
^ ^3.0 ^3.1 Howden BP, Grayson ML. Dumb and dumber--the potential waste of a useful antistaphylococcal agent: emerging fusidic acid resistance in Staphylococcus aureus. Clinical Infectious Diseases. February 2006, 42 (3): 394–400. PMID 16392088. doi:10.1086/499365  .
^ Moriarty SR, Clark K, Scott D, Degenhardt TP, Fernandes P, Craft JC, Corey GR, Still JG and Das A (2010). 50th Interscience Conference on Antimicrobial Agents and Chemotherapy, Abstract L1-1762
^ Mason BW, Howard AJ, Magee JT. Fusidic acid resistance in community isolates of methicillin-susceptible Staphylococcus aureus and fusidic acid prescribing. The Journal of Antimicrobial Chemotherapy. April 2003, 51 (4): 1033–1036. PMID 12654748. doi:10.1093/jac/dkg190  .
^ Sommer S, Bojar R, Cunliffe WJ, Holland D, Holland KT, Naags H. Investigation of the mechanism of action of 2% fusidic acid lotion in the treatment of acne vulgaris. Clinical and Experimental Dermatology. September 1997, 22 (5): 211–215. PMID 9536540. doi:10.1046/j.1365-2230.1997.2530670.x.

外部链接

Fusidic acid bound to proteins （页面存档备份，存于互联网档案馆） in the PDB

[1] Falagas ME, Grammatikos AP, Michalopoulos A. Potential of old-generation antibiotics to address current need for new antibiotics. Expert Rev Anti Infect Ther. 2008; 6(5):593-600 doi:10.1586/14787210.6.5.593 PMID 18847400

[Collignon-1999-2] Collignon P, Turnidge J. Fusidic acid in vitro activity. International Journal of Antimicrobial Agents. August 1999, 12 (Supplement 2): S45–S58. PMID 10528786. doi:10.1016/s0924-8579(98)00073-9.

[Howden2006-3] 3.0 ^3.1 Howden BP, Grayson ML. Dumb and dumber--the potential waste of a useful antistaphylococcal agent: emerging fusidic acid resistance in Staphylococcus aureus. Clinical Infectious Diseases. February 2006, 42 (3): 394–400. PMID 16392088. doi:10.1086/499365  .

[Moriarty-4] Moriarty SR, Clark K, Scott D, Degenhardt TP, Fernandes P, Craft JC, Corey GR, Still JG and Das A (2010). 50th Interscience Conference on Antimicrobial Agents and Chemotherapy, Abstract L1-1762

[5] Mason BW, Howard AJ, Magee JT. Fusidic acid resistance in community isolates of methicillin-susceptible Staphylococcus aureus and fusidic acid prescribing. The Journal of Antimicrobial Chemotherapy. April 2003, 51 (4): 1033–1036. PMID 12654748. doi:10.1093/jac/dkg190  .

[6] Sommer S, Bojar R, Cunliffe WJ, Holland D, Holland KT, Naags H. Investigation of the mechanism of action of 2% fusidic acid lotion in the treatment of acne vulgaris. Clinical and Experimental Dermatology. September 1997, 22 (5): 211–215. PMID 9536540. doi:10.1046/j.1365-2230.1997.2530670.x.

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