群孕酮

化合物

群孕酮(英语:Trengestone,商品名为ReteroidRetroidRetrone)是一种黄体制剂药物,曾经用于治疗月经失调,但现已不再使用[2][3][4][5][6]

群孕酮
临床资料
商品名英语Drug nomenclatureReteroid, Retroid, Retrone
其他名称Ro 4-8347; Triengestone; 1,6-Didehydro-6-chlororetroprogesterone; 6-Chloro-9β-10α-pregna-1,4,6-triene-3,20-dione
给药途径By mouth
药物类别英语Drug classProgestin; Progestogen
ATC码
  • 未分配
法律规范状态
法律规范
  • 处方药(-only)
药物动力学数据
生物利用度≥41–46% (based on urinary excretion)[1]
药物代谢Liver
代谢产物20α-Dihydrotrengestone[1]
生物半衰期• Trengestone: very short[1]
20α-DHTG: 8–14 hours[1]
排泄途径Urine: 41–46%[1]
Feces: 30% (unchanged)[1]
识别信息
  • (8S,9S,10R,13S,14S,17S)-17-acetyl-6-chloro-10,13-dimethyl-8,9,11,12,14,15,16,17-octahydrocyclopenta[a]phenanthren-3-one
CAS号5192-84-7
PubChem CID
ChemSpider
UNII
ChEBI
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.023.617 编辑维基数据链接
化学信息
化学式C21H25ClO2
摩尔质量344.879 g/mol
3D模型(JSmol英语JSmol
  • CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2C=C(C4=CC(=O)C=C[C@]34C)Cl)C
  • InChI=1S/C21H25ClO2/c1-12(23)15-4-5-16-14-11-19(22)18-10-13(24)6-8-21(18,3)17(14)7-9-20(15,16)2/h6,8,10-11,14-17H,4-5,7,9H2,1-3H3/t14-,15+,16-,17-,20+,21+/m0/s1
  • Key:USXVMPAWZOOYDE-HGUQNLGYSA-N

参考文献

编辑
  1. ^ 1.0 1.1 1.2 1.3 1.4 1.5 Dixon R, Tormey P, Darragh A. Disposition of the retro-steroid progestogen, 6-chloro-9beta, 10alpha-pregna-1,4,6-triene-3,20-dione (Ro 4-8347), in man. Contraception. March 1975, 11 (3): 339–46. PMID 1116370. doi:10.1016/0010-7824(75)90042-6. 
  2. ^ J. Elks. The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014: 259– [2019-06-07]. ISBN 978-1-4757-2085-3. (原始内容存档于2021-06-06). 
  3. ^ Pascale Brudon. Médicaments pour tous en l'an 2000?: les multinationales pharmaceutiques suisses face au tiers monde : l'exemple du Mexique. Editions d'en bas. 1983: 93– [2019-06-07]. ISBN 978-2-8290-0039-3. (原始内容存档于2021-06-17). 
  4. ^ Dr. Ian Morton; I.K. Morton; Judith M. Hall. Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. 31 October 1999: 279– [2019-06-07]. ISBN 978-0-7514-0499-9. (原始内容存档于2021-06-06). 
  5. ^ J. Horsky; J. Presl. Ovarian Function and its Disorders: Diagnosis and Therapy. Springer Science & Business Media. 6 December 2012: 329– [2019-06-07]. ISBN 978-94-009-8195-9. (原始内容存档于2021-10-21). 
  6. ^ 存档副本. [2020-09-17]. (原始内容存档于2020-08-18).